학술논문
Comprehensive hematological reference intervals in a healthy adult male population.
Document Type
Academic Journal
Author
Ghazizadeh H; Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.; Kathryn Bohn M; CALIPER Program, Divisions of Clinical Biochemistry, Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.; Kardagh Polus R; Department of Basic Science, College of Medicine, Hawler Medical University, Erbil, Kurdistan Region-Iraq.; Abdulkarimi R; Independent Scholar, Department of Environment, Boukan Office, Boukan, Iran. Orcid ID: https://orcid.org/0000-0003-1921-5493.; Mahdavizadeh V; Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Ghaffarian Zirak R; Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Kamel Khodabandeh A; Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Zare-Feyzabadi R; Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.; Timar A; Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Mohammadi-Bajgiran M; Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Oladi MR; International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Esmaily H; Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Sharifan P; International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Sahranavard T; Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Kazemi E; Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.; Ekhteraee Toosi MS; Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran.; Taghizadeh N; Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran.; Najar Sedgh Doust F; Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran.; Ferns GA; Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK.; Adeli K; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Ghayour-Mobarhan M; Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Source
Publisher: C.M.B. Association Country of Publication: France NLM ID: 9216789 Publication Model: Electronic Cited Medium: Internet ISSN: 1165-158X (Electronic) Linking ISSN: 01455680 NLM ISO Abbreviation: Cell Mol Biol (Noisy-le-grand) Subsets: MEDLINE
Subject
Language
English
Abstract
Reference intervals (RIs) are important tools for improving medical decision-making. Hematology reference values can be influenced by important covariates such as genetic and environmental factors, rendering it essential to define RIs for specific populations. Therefore, we aimed to establish accurate and robust RIs for hematological markers in a healthy adult male Iranian population. This cross-sectional study was conducted in a population of 723 males aged 20-60 years old. Hematological parameters were routinely measured using a Sysmex auto analyser system (KX-21 N). The quality of assays was monitored using commercial quality control samples. The nonparametric rank method, as recommended by the Clinical and Laboratory Standards Institute (CLSI) guidelines, was used to calculate the 2.5th and 97.5th percentiles as the lower and upper reference limits, respectively. Of the 12 hematological parameters assessed, only mean platelet volume (MPV) demonstrated significant age-specific differences, requiring two partitions from 20 to 35 years (8.7-12.2 fL) and 35 to 65 years (8.5-11.5 fL). The remaining hematological parameters (e.g. leukocyte, erythrocyte, and platelet parameters) could be defined by one age range. This study established RIs for 12 routinely used hematological parameters in a healthy male population living in the northeastern region of Iran. Established RIs differed from those previously reported by other cohorts, highlighting the importance of population-specific RIs.