학술논문
[Development of fluorescent imaging sensors based on proteins].
Document Type
Academic Journal
Author
Hario S; Department of Chemistry, Graduate School of Science, The University of Tokyo.; Takeuchi S; Department of Chemistry, Graduate School of Science, The University of Tokyo.; Campbell RE; Department of Chemistry, Graduate School of Science, The University of Tokyo.; Terai T; Department of Chemistry, Graduate School of Science, The University of Tokyo.
Source
Publisher: Nippon Yakuri Gakkai Country of Publication: Japan NLM ID: 0420550 Publication Model: Print Cited Medium: Print ISSN: 0015-5691 (Print) Linking ISSN: 00155691 NLM ISO Abbreviation: Nihon Yakurigaku Zasshi Subsets: MEDLINE
Subject
Language
Japanese
ISSN
0015-5691
Abstract
Fluorescent imaging sensors based on genetically-encoded and biocompatible proteins have become important tools in medical and biological research due to their high spatiotemporal resolution and ease of use. Protein engineering has led to the development of imaging sensors that visualize changes in the concentration of various target molecules/ions, such as calcium ions. In addition, the development of chemigenetic sensors based on complexes of proteins and synthetic molecules has been gaining momentum in recent years. In this article, the latest research trends in the development of these imaging sensors are introduced, with focus on the sensors developed by our group.