학술논문
Oral administration of nanomicelle curcumin in the prevention of radiotherapy-induced mucositis in head and neck cancers.
Document Type
Academic Journal
Author
Delavarian Z; Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Pakfetrat A; Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Ghazi A; Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Jaafari MR; Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.; Homaei Shandiz F; Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Dalirsani Z; Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Mohammadpour AH; Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Rahimi HR; Department of New Science and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Source
Publisher: American Dental Association Country of Publication: United States NLM ID: 8103755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1754-4505 (Electronic) Linking ISSN: 02751879 NLM ISO Abbreviation: Spec Care Dentist
Subject
Language
English
Abstract
Oral mucositis (OM) is a complication of head and neck cancer (HNC) therapy with negative impact on the quality of life. Although definitive treatment has not yet been established, there is interest towards the use of natural compounds owing to their few side effects. Curcumin has a variety of biological and pharmacological properties including anticancer and anti-inflammatory effects.
Aim: The aim of this study is to evaluate the effect of curcumin in the form of nanomicelle on OM in HNC patients receiving radiotherapy.
Methods: In this clinical trial, 32 HNC patients were allocated to case and control groups, and respectively received nanocurcumin or placebo during radiotherapy.
Results: We found a statistically significant difference in the severity of mucositis between the 2 groups at all visits. In contrast to the control-group patients, who all developed OM in the 2nd week of radiotherapy, only 32% of the case group developed OM with no obvious oral or systemic side effects.
Conclusion: Our data show that nanomicelle curcumin is an effective agent in the prevention of OM or reducing its severity. Thus, the administration of nanocurcumin can be considered as a reasonable approach to hinder the development of OM in HNC patients requiring radiotherapy.
(© 2019 Special Care Dentistry Association and Wiley Periodicals, Inc.)
Aim: The aim of this study is to evaluate the effect of curcumin in the form of nanomicelle on OM in HNC patients receiving radiotherapy.
Methods: In this clinical trial, 32 HNC patients were allocated to case and control groups, and respectively received nanocurcumin or placebo during radiotherapy.
Results: We found a statistically significant difference in the severity of mucositis between the 2 groups at all visits. In contrast to the control-group patients, who all developed OM in the 2nd week of radiotherapy, only 32% of the case group developed OM with no obvious oral or systemic side effects.
Conclusion: Our data show that nanomicelle curcumin is an effective agent in the prevention of OM or reducing its severity. Thus, the administration of nanocurcumin can be considered as a reasonable approach to hinder the development of OM in HNC patients requiring radiotherapy.
(© 2019 Special Care Dentistry Association and Wiley Periodicals, Inc.)