학술논문
Acute effects of COREXIT EC9500A on cardiovascular functions in rats.
Document Type
Academic Journal
Author
Krajnak K; Engineering and Controls Technology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. ksk1@cdc.gov; Kan H; Waugh S; Miller GR; Johnson C; Roberts JR; Goldsmith WT; Jackson M; McKinney W; Frazer D; Kashon ML; Castranova V
Source
Publisher: Taylor & Francis Country of Publication: England NLM ID: 100960995 Publication Model: Print Cited Medium: Internet ISSN: 1528-7394 (Print) Linking ISSN: 00984108 NLM ISO Abbreviation: J Toxicol Environ Health A Subsets: MEDLINE
Subject
Language
English
ISSN
1528-7394
Abstract
These studies characterized cardiovascular responses after an acute inhalation exposure to COREXIT EC9500A, the oil dispersant used in the Deepwater Horizon oil spill. Male Sprague-Dawley rats underwent a single 5-h inhalation exposure to COREXIT EC9500A (average exposure level 27.12 mg/m(3)) or air. On d 1 and 7 following the exposure, rats were implanted with indwelling catheters and changes in heart rate and blood pressure were assessed in response to increasing levels of adrenoreceptor agonists. A separate group of rats was euthanized at the same time points, ventral tail arteries were dissected, and vascular tone along with dose-dependent responses to vasoconstricting and dilating factors were assessed in vitro. Agonist-induced dose-dependent increases in heart rate and blood pressure were greater in COREXIT EC9500A-exposed than in air-exposed rats at 1 d but not 7 d after the exposure. COREXIT EC9500A exposure also induced a rise in basal tone and reduced responsiveness of tail arteries to acetylcholine-induced vasodilation at 1 d but not 7 d following the exposure. These findings demonstrate that an acute exposure to COREXIT EC9500A exerts transient effects on cardiovascular and peripheral vascular functions.