학술논문
Early Onset Obesity and Risk of Metabolic Syndrome Among Chilean Adolescents.
Document Type
Academic Journal
Author
Pacheco LS; University of California San Diego-San Diego State University Joint Doctoral Program in Public Health, La Jolla, California.; Blanco E; Division of Child Development and Community Health, Department of Pediatrics, University of California, San Diego, California.; University of Chile Doctoral Program in Public Health, Santiago, Chile.; Burrows R; Public Health Nutrition Unit, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile.; Reyes M; Public Health Nutrition Unit, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile.; Lozoff B; Center for Human Growth and Development, University of Michigan, Ann Arbor, Michigan.; Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan.; Gahagan S; Division of Child Development and Community Health, Department of Pediatrics, University of California, San Diego, California.; Center for Human Growth and Development, University of Michigan, Ann Arbor, Michigan.; Department of Pediatrics, University of California, San Diego, 9500 Gilman Dr, MC 0927, La Jolla, CA 92093-0927. Email: sgahagan@ucsd.edu.
Source
Publisher: U.S. Dept. of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion Country of Publication: United States NLM ID: 101205018 Publication Model: Electronic Cited Medium: Internet ISSN: 1545-1151 (Electronic) Linking ISSN: 15451151 NLM ISO Abbreviation: Prev Chronic Dis Subsets: MEDLINE
Subject
Language
English
Abstract
Introduction: Obesity and metabolic syndrome (MetS) indicators have increased globally among the pediatric population. MetS indicators in the young elevate their risk of cardiovascular disease and metabolic disorders later in life. This study examined early onset obesity as a risk factor for MetS risk in adolescence.
Methods: A cohort of Chilean participants (N = 673) followed from infancy was assessed at age 5 years and in adolescence (mean age, 16.8 y). Adiposity was measured at both time points; blood pressure and fasting blood samples were assessed in adolescence only. Early onset obesity was defined as a World Health Organization z score of 2 standard deviations (SDs) or more for body mass index (BMI) at age 5 years. We used linear regression to examine the association between early onset obesity and adolescent MetS risk z score, adjusting for covariates.
Results: Eighteen percent of participants had early onset obesity, and 50% of these remained obese in adolescence. Mean MetS risk z score in adolescence was significantly higher among those with early onset obesity than among those without (1.0; SD, 0.8 vs 0.2; SD, 0.8 [P < .001]). In the multivariable model, early onset obesity independently contributed to a higher MetS risk score in adolescence (β = 0.27, P < .001), controlling for obesity status at adolescence and sex, and explained 39% of the variance in MetS risk.
Conclusion: Early onset obesity as young as age 5 years relates to higher MetS risk.
Methods: A cohort of Chilean participants (N = 673) followed from infancy was assessed at age 5 years and in adolescence (mean age, 16.8 y). Adiposity was measured at both time points; blood pressure and fasting blood samples were assessed in adolescence only. Early onset obesity was defined as a World Health Organization z score of 2 standard deviations (SDs) or more for body mass index (BMI) at age 5 years. We used linear regression to examine the association between early onset obesity and adolescent MetS risk z score, adjusting for covariates.
Results: Eighteen percent of participants had early onset obesity, and 50% of these remained obese in adolescence. Mean MetS risk z score in adolescence was significantly higher among those with early onset obesity than among those without (1.0; SD, 0.8 vs 0.2; SD, 0.8 [P < .001]). In the multivariable model, early onset obesity independently contributed to a higher MetS risk score in adolescence (β = 0.27, P < .001), controlling for obesity status at adolescence and sex, and explained 39% of the variance in MetS risk.
Conclusion: Early onset obesity as young as age 5 years relates to higher MetS risk.