학술논문
Association of the NOS3 Gene Polymorphisms with the Risk of Atopic Dermatitis in Children.
Document Type
Academic Journal
Author
Svitich ОА; I. I. Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia. svitichoa@yandex.ru.; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia. svitichoa@yandex.ru.; Kudryavtseva АV; I. I. Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.; Slyusareva ЕS; Rostov State Medical University, Ministry of Health of the Russian Federation, Rostov, Russia.; Kravtsova ЕО; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.; Meremianina ЕА; I. I. Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.; Bystritskaya ЕP; I. I. Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.; Sobolev VV; I. I. Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.; Ryabtsev АI; I. I. Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.; Potapova АB; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.; Zverev VV; I. I. Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
Source
Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-8221 (Electronic) Linking ISSN: 00074888 NLM ISO Abbreviation: Bull Exp Biol Med Subsets: MEDLINE
Subject
Language
English
Abstract
We studied association of polymorphic markers Glu298Asp (rs1799983), C774T (rs1549758), and T786C (rs2070744) of the NOS3 gene with the risk of atopic dermatitis. It was found that T786C polymorphic marker of the NOS3 gene is associated with lower risk of erythematosquamous lichenoid atopic dermatitis. A significant association between the homozygous CC genotype in locus 786 of the NOS3 gene and the development of erythematosquamous atopic dermatitis with lichenification was revealed. The homozygous CC genotype can be considered as a risk factor of erythematosquamous atopic dermatitis with lichenification.