학술논문
Long-term cardiovascular consequences of adolescent anorexia nervosa.
Document Type
Academic Journal
Author
Springall GAC; Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia. gabriella.springall@mcri.edu.au.; Murdoch Children's Research Institute, Parkville, VIC, Australia. gabriella.springall@mcri.edu.au.; Caughey M; Department of Adolescent Medicine, Monash Children's Hospital, Clayton, VIC, Australia.; Zannino D; Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Parkville, VIC, Australia.; Kyprianou K; Department of Adolescent Medicine, Monash Children's Hospital, Clayton, VIC, Australia.; Monash University, Clayton, VIC, Australia.; Mynard JP; Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia.; Murdoch Children's Research Institute, Parkville, VIC, Australia.; Department of Biomedical Engineering, University of Melbourne, Parkville, VIC, Australia.; Rudolph S; Department of Paediatric Medicine, Austin Health, Heidelberg, VIC, Australia.; Cheong J; Murdoch Children's Research Institute, Parkville, VIC, Australia.; Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, VIC, Australia.; Neonatal Services, Royal Women's Hospital, Parkville, VIC, Australia.; Yeo M; Department of Adolescent Medicine, Royal Children's Hospital, Parkville, VIC, Australia.; Cheung MMH; Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia.; Murdoch Children's Research Institute, Parkville, VIC, Australia.; Department of Cardiology, Royal Children's Hospital, Parkville, VIC, Australia.
Source
Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 0100714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0447 (Electronic) Linking ISSN: 00313998 NLM ISO Abbreviation: Pediatr Res Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Anorexia nervosa (AN) is associated with maladaptive cardiovascular changes. This study investigated whether individuals who recovered from AN during adolescence experience long-term cardiovascular risk in early adulthood.
Methods: Former AN patients discharged from the Royal Children's and Monash Children's Hospital Eating Disorder Services in Melbourne, Australia underwent cardiovascular testing. Measurements were performed using an oscillometric device for blood pressure and pulse wave velocity, ultrasound for carotid wall structure/function, resting electrocardiogram for heart-rate variability, and the EndoPat 2000 (Itamar) system for endothelial function. Patient measures were compared to healthy controls and/or normal thresholds.
Results: Ninety-one percent of the former AN patients (N = 22) and controls (N = 66) were female, aged approximately 25 years, with a healthy body mass index. The mean time interval from AN recovery to participation was 7.4 years. Pulse wave velocity was lower in the former AN patients than controls. Carotid intima-media thickness was not different; however, carotid distensibility and compliance were lower, and the elastic modulus higher in the former AN patients. Greater vagal tone was observed and endothelial dysfunction was evident in 46% of the former patients.
Conclusions: Young adults who recovered from adolescent AN exhibit persistent cardiovascular adaptations. Routine cardiovascular monitoring could manage potential disease risk.
Impact: Cardiovascular complications are common in patients with anorexia nervosa (AN) and population studies have revealed that developmental adaptations in response to undernutrition have long-term consequences for cardiovascular health. In this study of young adults treated for AN during adolescence, there was evidence of increased carotid artery stiffness, reduced aortic stiffness, vagal hyperactivity, and endothelial dysfunction in early adulthood when compared to healthy controls. It is important to consider the cardiovascular health of patients with AN beyond achieving medical stability. Interventions that monitor cardiovascular health could minimise the burden of future cardiovascular disease.
(© 2023. The Author(s).)
Methods: Former AN patients discharged from the Royal Children's and Monash Children's Hospital Eating Disorder Services in Melbourne, Australia underwent cardiovascular testing. Measurements were performed using an oscillometric device for blood pressure and pulse wave velocity, ultrasound for carotid wall structure/function, resting electrocardiogram for heart-rate variability, and the EndoPat 2000 (Itamar) system for endothelial function. Patient measures were compared to healthy controls and/or normal thresholds.
Results: Ninety-one percent of the former AN patients (N = 22) and controls (N = 66) were female, aged approximately 25 years, with a healthy body mass index. The mean time interval from AN recovery to participation was 7.4 years. Pulse wave velocity was lower in the former AN patients than controls. Carotid intima-media thickness was not different; however, carotid distensibility and compliance were lower, and the elastic modulus higher in the former AN patients. Greater vagal tone was observed and endothelial dysfunction was evident in 46% of the former patients.
Conclusions: Young adults who recovered from adolescent AN exhibit persistent cardiovascular adaptations. Routine cardiovascular monitoring could manage potential disease risk.
Impact: Cardiovascular complications are common in patients with anorexia nervosa (AN) and population studies have revealed that developmental adaptations in response to undernutrition have long-term consequences for cardiovascular health. In this study of young adults treated for AN during adolescence, there was evidence of increased carotid artery stiffness, reduced aortic stiffness, vagal hyperactivity, and endothelial dysfunction in early adulthood when compared to healthy controls. It is important to consider the cardiovascular health of patients with AN beyond achieving medical stability. Interventions that monitor cardiovascular health could minimise the burden of future cardiovascular disease.
(© 2023. The Author(s).)