학술논문
Mental health in young adults born extremely preterm or extremely low birthweight with contemporary neonatal intensive care.
Document Type
Academic Journal
Author
Burnett AC; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia.; Premature Infant Follow-Up Program, Royal Women's Hospital, Melbourne, Australia.; Neonatal Medicine, Royal Children's Hospital, Melbourne, Australia.; Department of Paediatrics, University of Melbourne, Melbourne, Australia.; Mainzer RM; Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Melbourne, Australia.; Doyle LW; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia.; Premature Infant Follow-Up Program, Royal Women's Hospital, Melbourne, Australia.; Department of Paediatrics, University of Melbourne, Melbourne, Australia.; Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia.; Lee KJ; Department of Paediatrics, University of Melbourne, Melbourne, Australia.; Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Melbourne, Australia.; Anderson PJ; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia.; Turner Institute for Brain & Mental Health, School of Psychological Sciences, Monash University, Melbourne, Australia.; Zannino D; Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Melbourne, Australia.; Duff J; Premature Infant Follow-Up Program, Royal Women's Hospital, Melbourne, Australia.; Mercy Hospital for Women, Heidelberg, Victoria, Australia.; Patton GC; Department of Paediatrics, University of Melbourne, Melbourne, Australia.; Centre for Adolescent Health, Murdoch Children's Research Institute, Melbourne, Australia.; Cheong JLY; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia.; Premature Infant Follow-Up Program, Royal Women's Hospital, Melbourne, Australia.; Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia.
Source
Publisher: Cambridge University Press Country of Publication: England NLM ID: 1254142 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-8978 (Electronic) Linking ISSN: 00332917 NLM ISO Abbreviation: Psychol Med Subsets: MEDLINE
Subject
Language
English
Abstract
Background: For infants born in the contemporary era of neonatal care, little is known about adult mental health outcomes of extremely preterm birth (EP; <28 weeks' gestation) or extremely low birthweight (ELBW; <1000 g). This study aimed to compare attention deficit hyperactivity disorder (ADHD), anxiety, mood, and substance use disorder prevalence in young adults born EP/ELBW and normal birthweight (NBW; >2499 g) controls, and to compare change in prevalence of mental health symptoms and disorders from 18 to 25 years.
Methods: Participants were a prospective geographical cohort of 297 consecutive survivors born EP/ELBW during 1991-1992 and 260 NBW controls. At age 25 years, 174 EP/ELBW and 139 NBW participants completed the Adult ADHD Rating Scale, Structured Clinical Interview for DSM-IV Disorders, Beck Anxiety Inventory, and Center for Epidemiologic Studies Depression Scale-Revised. Data from follow-up at 18 years were also utilized. Multiple imputation was used to account for attrition.
Results: Mental health outcomes at 25 years were similar between groups: prevalence rates were ADHD 7% v. 5%; anxiety 32% v. 27%; mood 38% v. 35%; substance use 12% v. 14% in the EP/ELBW and NBW groups, respectively. In both groups, ADHD declined between 18 and 25 years [odds ratio (OR) per year = 0.87, 95% confidence interval (CI) 0.79-0.95], and generalized anxiety disorder and major depressive episode became more common (OR 1.22, 95% CI 1.10-1.35 per year; OR 1.20, 95% CI 1.10-1.30 respectively).
Conclusions: This contemporary EP/ELBW cohort has comparable young adult mental health outcomes to controls, and similar patterns of change in mental health from late adolescence.
Methods: Participants were a prospective geographical cohort of 297 consecutive survivors born EP/ELBW during 1991-1992 and 260 NBW controls. At age 25 years, 174 EP/ELBW and 139 NBW participants completed the Adult ADHD Rating Scale, Structured Clinical Interview for DSM-IV Disorders, Beck Anxiety Inventory, and Center for Epidemiologic Studies Depression Scale-Revised. Data from follow-up at 18 years were also utilized. Multiple imputation was used to account for attrition.
Results: Mental health outcomes at 25 years were similar between groups: prevalence rates were ADHD 7% v. 5%; anxiety 32% v. 27%; mood 38% v. 35%; substance use 12% v. 14% in the EP/ELBW and NBW groups, respectively. In both groups, ADHD declined between 18 and 25 years [odds ratio (OR) per year = 0.87, 95% confidence interval (CI) 0.79-0.95], and generalized anxiety disorder and major depressive episode became more common (OR 1.22, 95% CI 1.10-1.35 per year; OR 1.20, 95% CI 1.10-1.30 respectively).
Conclusions: This contemporary EP/ELBW cohort has comparable young adult mental health outcomes to controls, and similar patterns of change in mental health from late adolescence.