학술논문
Exhaled breath condensate as bioanalyte: from collection considerations to biomarker sensing.
Document Type
Academic Journal
Author
Szunerits S; Univ. Lille, CNRS, Centrale Lille, Univ. Polytechnique Hauts-de-France, UMR 8520 - IEMN, 59000, Lille, France. sabine.szunerits@univ-lille.fr.; Laboratory for Life Sciences and Technology (LiST), Danube Private University, Krems, 3500, Austria. sabine.szunerits@univ-lille.fr.; Dӧrfler H; Laboratory for Life Sciences and Technology (LiST), Danube Private University, Krems, 3500, Austria.; Pagneux Q; Univ. Lille, CNRS, Centrale Lille, Univ. Polytechnique Hauts-de-France, UMR 8520 - IEMN, 59000, Lille, France.; Daniel J; e-DiagMetrics GmbH, Parkring 2, Vienna, 1010, Austria.; Wadekar S; e-DiagMetrics GmbH, Parkring 2, Vienna, 1010, Austria.; Woitrain E; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011- EGID, 59000, Lille, France.; Ladage D; Laboratory for Life Sciences and Technology (LiST), Danube Private University, Krems, 3500, Austria.; Montaigne D; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011- EGID, 59000, Lille, France.; Boukherroub R; Univ. Lille, CNRS, Centrale Lille, Univ. Polytechnique Hauts-de-France, UMR 8520 - IEMN, 59000, Lille, France.
Source
Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101134327 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-2650 (Electronic) Linking ISSN: 16182642 NLM ISO Abbreviation: Anal Bioanal Chem Subsets: MEDLINE
Subject
Language
English
Abstract
Since the SARS-CoV-2 pandemic, the potential of exhaled breath (EB) to provide valuable information and insight into the health status of a person has been revisited. Mass spectrometry (MS) has gained increasing attention as a powerful analytical tool for clinical diagnostics of exhaled breath aerosols (EBA) and exhaled breath condensates (EBC) due to its high sensitivity and specificity. Although MS will continue to play an important role in biomarker discovery in EB, its use in clinical setting is rather limited. EB analysis is moving toward online sampling with portable, room temperature operable, and inexpensive point-of-care devices capable of real-time measurements. This transition is happening due to the availability of highly performing biosensors and the use of wearable EB collection tools, mostly in the form of face masks. This feature article will outline the last developments in the field, notably the novel ways of EBA and EBC collection and the analytical aspects of the collected samples. The inherit non-invasive character of the sample collection approach might open new doors for efficient ways for a fast, non-invasive, and better diagnosis.
(© 2022. Springer-Verlag GmbH Germany, part of Springer Nature.)
(© 2022. Springer-Verlag GmbH Germany, part of Springer Nature.)