학술논문
Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment.
Document Type
Academic Journal
Author
Ivić V; Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.; Zjalić M; Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.; Blažetić S; Department of Biology, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.; Fenrich M; Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.; Labak I; Department of Biology, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.; Scitovski R; School of Applied Mathematics and Computer Science, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.; Szűcs KF; Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, Interdisciplinary Excellence Centre, University of Szeged, Szeged, Hungary.; Ducza E; Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary.; Tábi T; Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary.; Bagamery F; Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary.; Szökő É; Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary.; Vuković R; Department of Biology, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.; Rončević A; Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.; Department of Neurosurgery, Osijek University Hospital, Osijek, Croatia.; Mandić D; Clinical Institute of Laboratory Diagnostics, Osijek University Hospital, Osijek, Croatia.; Department of Medical Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.; Debeljak Ž; Clinical Institute of Laboratory Diagnostics, Osijek University Hospital, Osijek, Croatia.; Department of Pharmacology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.; Berecki M; Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.; Balog M; Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.; Seres-Bokor A; Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary.; Sztojkov-Ivanov A; Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary.; Hajagos-Tóth J; Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, Interdisciplinary Excellence Centre, University of Szeged, Szeged, Hungary.; Gajović S; Croatian Institute for Brain Research, and BIMIS - Biomedical Research Institute Šalata, University of Zagreb School of Medicine, Zagreb, Croatia.; Imširović A; Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.; Bakula M; Department of Clinical Pathology and Forensic Medicine, Osijek University Hospital, Osijek, Croatia.; Mahiiovych S; Department of Therapy № 1 and Medical Diagnostics, Hematology and Transfusiology, Faculty of Postgraduate Education, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.; Gaspar R; Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, Interdisciplinary Excellence Centre, University of Szeged, Szeged, Hungary.; Vari SG; Cedars-Sinai Medical Center, International Research and Innovation in Medicine Program, Los Angeles, CA, United States.; Heffer M; Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Source
Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE
Subject
Language
English
ISSN
1664-2392
Abstract
Aim/introduction: The study aimed to determine the effectiveness of early antidiabetic therapy in reversing metabolic changes caused by high-fat and high-sucrose diet (HFHSD) in both sexes.
Methods: Elderly Sprague-Dawley rats, 45 weeks old, were randomized into four groups: a control group fed on the standard diet (STD), one group fed the HFHSD, and two groups fed the HFHSD along with long-term treatment of either metformin (HFHSD+M) or liraglutide (HFHSD+L). Antidiabetic treatment started 5 weeks after the introduction of the diet and lasted 13 weeks until the animals were 64 weeks old.
Results: Unexpectedly, HFHSD-fed animals did not gain weight but underwent significant metabolic changes. Both antidiabetic treatments produced sex-specific effects, but neither prevented the onset of prediabetes nor diabetes.
Conclusion: Liraglutide vested benefits to liver and skeletal muscle tissue in males but induced signs of insulin resistance in females.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Ivić, Zjalić, Blažetić, Fenrich, Labak, Scitovski, Szűcs, Ducza, Tábi, Bagamery, Szökő, Vuković, Rončević, Mandić, Debeljak, Berecki, Balog, Seres-Bokor, Sztojkov-Ivanov, Hajagos-Tóth, Gajović, Imširović, Bakula, Mahiiovych, Gaspar, Vari and Heffer.)
Methods: Elderly Sprague-Dawley rats, 45 weeks old, were randomized into four groups: a control group fed on the standard diet (STD), one group fed the HFHSD, and two groups fed the HFHSD along with long-term treatment of either metformin (HFHSD+M) or liraglutide (HFHSD+L). Antidiabetic treatment started 5 weeks after the introduction of the diet and lasted 13 weeks until the animals were 64 weeks old.
Results: Unexpectedly, HFHSD-fed animals did not gain weight but underwent significant metabolic changes. Both antidiabetic treatments produced sex-specific effects, but neither prevented the onset of prediabetes nor diabetes.
Conclusion: Liraglutide vested benefits to liver and skeletal muscle tissue in males but induced signs of insulin resistance in females.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Ivić, Zjalić, Blažetić, Fenrich, Labak, Scitovski, Szűcs, Ducza, Tábi, Bagamery, Szökő, Vuković, Rončević, Mandić, Debeljak, Berecki, Balog, Seres-Bokor, Sztojkov-Ivanov, Hajagos-Tóth, Gajović, Imširović, Bakula, Mahiiovych, Gaspar, Vari and Heffer.)