학술논문
Synthetic Methodologies and Therapeutic Potential of Indole-3-Carbinol (I3C) and Its Derivatives.
Document Type
Academic Journal
Author
Centofanti F; Department of Biomedicine and Prevention, Tor Vergata University of Rome, 00133 Rome, Italy.; Buono A; Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy.; Verboni M; Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy.; Tomino C; Scientific Direction-IRCCS San Raffaele Rome, 00166 Rome, Italy.; Lucarini S; Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy.; Duranti A; Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy.; Pandolfi PP; William N. Pennington Cancer Institute, Renown Health, Nevada System of Higher Education, Reno, NV 89502, USA.; Novelli G; Department of Biomedicine and Prevention, Tor Vergata University of Rome, 00133 Rome, Italy.; Department of Pharmacology, School of Medicine, University of Nevada, Reno, NV 89557, USA.
Source
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print) Linking ISSN: 14248247 NLM ISO Abbreviation: Pharmaceuticals (Basel) Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
1424-8247
Abstract
Indole-3-carbinol (I3C) is a natural product contained in vegetables belonging to the Brassicaceae family and has been studied in recent decades for its biological and pharmacological properties. Herein, we will analyze: (1) the biosynthetic processes and synthetic procedures through which I3C and its main derivatives have been obtained; (2) the characteristics that lead to believe that both I3C and its derivatives are responsible for several important activities-in particular, antitumor and antiviral, through insights concerning in vitro assays and in vivo tests; (3) the mechanisms of action of the most important compounds considered; (4) the potential social impact that the enhancement of the discussed molecules can have in the prevention and treatment of the pathologies' examined field-first of all, those related to respiratory tract disorders and cancer.