학술논문
Dramatic Increase in Incidence of Ulcerative Colitis and Crohn's Disease (1988-2011): A Population-Based Study of French Adolescents.
Document Type
Academic Journal
Author
Ghione S; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Lille University Jeanne de Flandre Children's Hospital and Faculty of Medicine, Lille, France.; Sarter H; Public Health, Epidemiology and Economic Health, Epimad registry, Regional house of clinical research, Lille Hospital and University, Lille, France.; Lille Inflammation Research International Center LIRIC-UMR 995 Inserm-'IBD and environmental factors: epidemiology and functional analyses', Lille University, Lille, France.; Fumery M; Gastroenterology Unit, Epimad registry, Amiens Hospital and University, Amiens, France.; Armengol-Debeir L; Gastroenterology Unit, Epimad registry, Rouen Hospital and University, Rouen, France.; Savoye G; Gastroenterology Unit, Epimad registry, Rouen Hospital and University, Rouen, France.; Ley D; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Lille University Jeanne de Flandre Children's Hospital and Faculty of Medicine, Lille, France.; Lille Inflammation Research International Center LIRIC-UMR 995 Inserm-'IBD and environmental factors: epidemiology and functional analyses', Lille University, Lille, France.; Spyckerelle C; Department of Pediatrics, St Vincent de Paul Hospital and Lille Catholic University, Lille, France.; Pariente B; Lille Inflammation Research International Center LIRIC-UMR 995 Inserm-'IBD and environmental factors: epidemiology and functional analyses', Lille University, Lille, France.; Gastroenterology Unit, Epimad registry, Lille Hospital and University, Lille, France.; Peyrin-Biroulet L; Gastroenterology Unit, Inserm U954, Nancy Hospital and University, Nancy, France.; Turck D; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Lille University Jeanne de Flandre Children's Hospital and Faculty of Medicine, Lille, France.; Lille Inflammation Research International Center LIRIC-UMR 995 Inserm-'IBD and environmental factors: epidemiology and functional analyses', Lille University, Lille, France.; Gower-Rousseau C; Public Health, Epidemiology and Economic Health, Epimad registry, Regional house of clinical research, Lille Hospital and University, Lille, France.; Lille Inflammation Research International Center LIRIC-UMR 995 Inserm-'IBD and environmental factors: epidemiology and functional analyses', Lille University, Lille, France.; Andre JM; Antonietti M; Aouakli A; Armand A; Aroichane I; Assi F; Aubet JP; Auxenfants E; Ayafi-Ramelot F; Bankovski D; Barbry B; Bardoux N; Baron P; Baudet A; Bazin B; Bebahani A; Becqwort JP; Benet V; Benali H; Benguigui C; Soussan BE; Bental A; Berkelmans I; Bernet J; Bernou K; Bernou-Dron C; Bertot P; Bertiaux-Vandaële N; Bertrand V; Billoud E; Biron N; Bismuth B; Bleuet M; Blondel F; Blondin V; Bohon P; Boniface E; Bonnière P; Bonvarlet E; Bonvarlet P; Boruchowicz A; Bostvironnois R; Boualit M; Bouche B; Boudaillez C; Bourgeaux C; Bourgeois M; Bourguet A; Bourienne A; Branche J; Bray G; Brazier F; Breban P; Brihier H; Brung-Lefebvre V; Bulois P; Burgiere P; Butel J; Canva JY; Canva-Delcambre V; Capron JP; Cardot F; Carpentier P; Cartier E; Cassar JF; Cassagnou M; Castex JF; Catala P; Cattan S; Catteau S; Caujolle B; Cayron G; Chandelier C; Chantre M; Charles J; Charneau T; Chavance-Thelu M; Chirita D; Choteau A; Claerbout JF; Clergue PY; Coevoet H; Cohen G; Collet R; Colombel JF; Coopman S; Corvisart J; Cortot A; Couttenier F; Crinquette JF; Crombe V; Dadamessi I; Dapvril V; Davion T; Dautreme S; Debas J; Degrave N; Dehont F; Delatre C; Delcenserie R; Delette O; Delgrange T; Delhoustal L; Delmotte JS; Demmane S; Deregnaucourt G; Descombes P; Desechalliers JP; Desmet P; Desreumaux P; Desseaux G; Desurmont P; Devienne A; Devouge E; Devred M; Devroux A; Dewailly A; Dharancy S; Di Fiore A; Djeddi D; Djedir R; Dreher-Duwat ML; Dubois R; Dubuque C; Ducatillon P; Duclay J; Ducrocq B; Ducrot F; Ducrotte P; Dufilho A; Duhamel C; Dujardin D; Dumant-Forest C; Dupas JL; Dupont F; Duranton Y; Duriez A; El Achkar K; El Farisi M; Elie C; Elie-Legrand MC; Elkhaki A; Eoche M; Evrard D; Evrard JP; Fatome A; Filoche B; Finet L; Flahaut M; Flamme C; Foissey D; Fournier P; Foutrein-Comes MC; Foutrein P; Fremond D; Frere T; Fumery M; Gallet P; Gamblin C; Ganga-Zandzou PS; Gérard R; Geslin G; Gheyssens Y; Ghossini N; Ghrib S; Gilbert T; Gillet B; Godard D; Godard P; Godchaux JM; Godchaux R; Goegebeur G; Goria O; Gottrand F; Gower P; Grandmaison B; Groux M; Guedon C; Guillard JF; Guillem L; Guillemot F; Guimber D; Haddouche B; Hakim S; Hanon D; Hautefeuille V; Heckestweiller P; Hecquet G; Hedde JP; Hellal H; Henneresse PE; Heyman B; Heraud M; Herve S; Hochain P; Houssin-Bailly L; Houcke P; Huguenin B; Iobagiu S; Ivanovic A; Iwanicki-Caron I; Janicki E; Jarry M; Jeu J; Joly JP; Jonas C; Katherin F; Kerleveo A; Khachfe A; Kiriakos A; Kiriakos J; Klein O; Kohut M; Kornhauser R; Koutsomanis D; Laberenne JE; Laffineur G; Lagarde M; Lannoy P; Lapchin J; Lapprand M; Laude D; Leblanc R; Lecieux P; Leclerc N; Le Couteulx C; Ledent J; Lefebvre J; Lefiliatre P; Legrand C; Le Grix A; Lelong P; Leluyer B; Lenaerts C; Lepileur L; Leplat A; Lepoutre-Dujardin E; Leroi H; Leroy MY; Lesage JP; Lesage X; Lesage J; Lescanne-Darchis I; Lescut J; Lescut D; Leurent B; Levy P; Lhermie M; Lion A; Lisambert B; Loire F; Louf S; Louvet A; Luciani M; Lucidarme D; Lugand J; Macaigne O; Maetz D; Maillard D; Mancheron H; Manolache O; Marks-Brunel AB; Marti R; Martin F; Martin G; Marzloff E; Mathurin P; Mauillon J; Maunoury V; Maupas JL; Mesnard B; Metayer P; Methari L; Meurisse B; Meurisse F; Michaud L; Mirmaran X; Modaine P; Monthe A; Morel L; Mortier PE; Moulin E; Mouterde O; Mudry J; Nachury M; Khac NE; Notteghem B; Ollevier V; Ostyn A; Ouraghi A; Ouvry D; Paillot B; Panien-Claudot N; Paoletti C; Papazian A; Parent B; Pariente B; Paris JC; Patrier P; Paupart L; Pauwels B; Pauwels M; Petit R; Piat M; Piotte S; Plane C; Plouvier B; Pollet E; Pommelet P; Pop D; Pordes C; Pouchain G; Prades P; Prevost A; Prevost JC; Quesnel B; Queuniet AM; Quinton JF; Rabache A; Rabelle P; Raclot G; Ratajczyk S; Rault D; Razemon V; Reix N; Revillon M; Richez C; Robinson P; Rodriguez J; Roger J; Roux JM; Rudelli A; Saber A; Savoye G; Schlosseberg P; Segrestin M; Seguy D; Serin M; Seryer A; Sevenet F; Shekh N; Silvie J; Simon V; Spyckerelle C; Talbodec N; Techy A; Thelu JL; Thevenin A; Thiebault H; Thomas J; Thorel JM; Tielman G; Tode M; Toisin J; Tonnel J; Touchais JY; Touze Y; Tranvouez JL; Triplet C; Turck D; Uhlen S; Vaillant E; Valmage C; Vanco D; Vandamme H; Vanderbecq E; Eecken VE; Vandermolen P; Vandevenne P; Vandeville L; Vandewalle A; Vandewalle C; Vaneslander P; Vanhoove JP; Vanrenterghem A; Varlet P; Vasies I; Verbiese G; Vernier-Massouille G; Vermelle P; Verne C; Vezilier-Cocq P; Vigneron B; Vincendet M; Viot J; Voiment YM; Wacrenier A; Waeghemaecker L; Wallez JY; Wantiez M; Wartel F; Weber J; Willocquet JL; Wizla N; Wolschies E; Zalar A; Zaouri B; Zellweger A; Ziade C
Source
Publisher: Wolters Kluwer Health Country of Publication: United States NLM ID: 0421030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1572-0241 (Electronic) Linking ISSN: 00029270 NLM ISO Abbreviation: Am J Gastroenterol Subsets: MEDLINE
Subject
Language
English
Abstract
Objectives: Few data are available to describe the changes in incidence of pediatric-onset inflammatory bowel disease (IBD). The aim of this study was to describe changes in incidence and phenotypic presentation of pediatric-onset IBD in northern France during a 24-year period.
Methods: Pediatric-onset IBD (<17 years) was issued from a population-based IBD study in France between 1988 and 2011. Age groups and digestive location were defined according to the Paris classification.
Results: 1,350 incident cases were recorded (8.3% of all IBD) including 990 Crohn's disease (CD), 326 ulcerative colitis (UC) and 34 IBD unclassified (IBDU). Median age at diagnosis was similar in CD (14.4 years (Q1=11.8-Q3=16.0)) and UC (14.0 years (11.0-16.0)) and did not change over time. There were significantly more males with CD (females/males=0.82) than UC (females/males=1.25) (P=0.0042). Median time between onset of symptoms and IBD diagnosis was consistently 3 months (1-6). Mean incidence was 4.4/105 for IBD overall (3.2 for CD, 1.1 for UC and 0.1 for IBDU). From 1988-1990 to 2009-2011, a dramatic increase in incidences of both CD and UC were observed in adolescents (10-16 years): for CD from 4.2 to 9.5/10 5 (+126%; P<0.001) and for UC, from 1.6 to 4.1/10 5 (+156%; P<0.001). No modification in age or location at diagnosis was observed in either CD or UC.
Conclusions: In this population-based study, CD and UC incidences increased dramatically in adolescents across a 24-year span, suggesting that one or more strong environmental factors may predispose this population to IBD.
Methods: Pediatric-onset IBD (<17 years) was issued from a population-based IBD study in France between 1988 and 2011. Age groups and digestive location were defined according to the Paris classification.
Results: 1,350 incident cases were recorded (8.3% of all IBD) including 990 Crohn's disease (CD), 326 ulcerative colitis (UC) and 34 IBD unclassified (IBDU). Median age at diagnosis was similar in CD (14.4 years (Q1=11.8-Q3=16.0)) and UC (14.0 years (11.0-16.0)) and did not change over time. There were significantly more males with CD (females/males=0.82) than UC (females/males=1.25) (P=0.0042). Median time between onset of symptoms and IBD diagnosis was consistently 3 months (1-6). Mean incidence was 4.4/10
Conclusions: In this population-based study, CD and UC incidences increased dramatically in adolescents across a 24-year span, suggesting that one or more strong environmental factors may predispose this population to IBD.