학술논문
Effect of ketanserin on intraoperative blood loss during total hip arthroplasty in elderly patients under general anaesthesia.
Document Type
Academic Journal
Author
van EE R; Department of Anaesthesiology, Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam, The Netherlands.; van Oene JC
Source
Publisher: Elsevier Country of Publication: England NLM ID: 0372541 Publication Model: Print Cited Medium: Print ISSN: 0007-0912 (Print) Linking ISSN: 00070912 NLM ISO Abbreviation: Br J Anaesth Subsets: MEDLINE
Subject
Language
English
ISSN
0007-0912
Abstract
We have studied the effect of ketanserin, a selective serotonin S2-receptor antagonist, on surgical bleeding in a double-blind, placebo-controlled study in elderly patients undergoing total hip arthroplasty. One group of patients (n = 9) received ketanserin 10 mg i.v. followed by an infusion of 0.075 mg kg-1 h-1. The second group (n = 8) received placebo. Both groups were comparable with regard to age, height and body weight. Mean intraoperative blood loss was 454 ml with ketanserin and 894 ml with placebo (P = 0.004; Wilcoxon two-sample test). Mean duration of the operation was less with ketanserin (112 min) than with placebo (134 min) (P = 0.004), but rate of blood loss was also less with ketanserin (4.1 vs 6.7 ml min-1; P = 0.03). In the ketanserin group, mean arterial pressures tended to be less than in the placebo group. Reductions in central venous pressure were similar in both groups. There were no complications in relation to the use of ketanserin.