학술논문
Sex-specific impact of major depressive disorder on 12-year change in glycaemic status: Results from a nationwide cohort study of adults without diabetes in Germany.
Document Type
Academic Journal
Author
Nübel J; Department of Epidemiology and Health Monitoring, Robert Koch Institute, Berlin, Germany.; Truthmann J; Department of Epidemiology and Health Monitoring, Robert Koch Institute, Berlin, Germany.; Department of Family Medicine, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; Heidemann C; Department of Epidemiology and Health Monitoring, Robert Koch Institute, Berlin, Germany.; Du Y; Department of Epidemiology and Health Monitoring, Robert Koch Institute, Berlin, Germany.; Paprott R; Department of Epidemiology and Health Monitoring, Robert Koch Institute, Berlin, Germany.; Hapke U; Department of Epidemiology and Health Monitoring, Robert Koch Institute, Berlin, Germany.; Kruse J; Department of Psychosomatic Medicine and Psychotherapy, University of Giessen, Giessen, Germany.; Department of Psychosomatic Medicine and Psychotherapy, University of Marburg, Marburg, Germany.; Scheidt-Nave C; Department of Epidemiology and Health Monitoring, Robert Koch Institute, Berlin, Germany.; Baumert J; Department of Epidemiology and Health Monitoring, Robert Koch Institute, Berlin, Germany.
Source
Publisher: Blackwell Science Country of Publication: England NLM ID: 8500858 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-5491 (Electronic) Linking ISSN: 07423071 NLM ISO Abbreviation: Diabet Med Subsets: MEDLINE
Subject
Language
English
Abstract
Aims: There is evidence for an increased type 2 diabetes (T2D) risk associated with depression, but its role for diabetes prevention remains unclear. This study aimed to add insight by investigating the impact of major depressive disorder (MDD) on prospective glycaemic changes.
Methods: The study was based on a cohort of n = 1,766 adults without diabetes (776 men, 990 women; 18-65 years of age) who participated in the mental health supplement of the German National Health Interview and Examination Survey (GNHIES98-MHS, 1997-1999) and in a follow-up survey (DEGS1, 2008-2011). Glycaemic status was defined as normoglycaemia [HbA1c < 39 mmol/mol (<5.7%)], prediabetes [39 ≤ HbA1c < 48 mmol/mol (5.7-6.4%)] and diabetes [HbA1c ≥ 48 mmol/mol (≥ 6.5%), diagnosed diabetes, or antidiabetic medication], and glycaemic changes categorized as 'remission', 'stability' and 'progression'. Baseline MDD was assessed via a modified German version of the WHO Composite International Diagnostic Interview. Multivariable logistic regressions were applied to analyse the association of MDD with glycaemic changes and incident T2D, adjusting for socio-demographics, lifestyle conditions, chronic diseases, antidepressant use and mental health care.
Results: MDD prevalence was 21.4% for women and 8.9% for men. Among women, MDD was associated with a lower chance for remission (RRR 0.43; 95% CI 0.23, 0.82). Among men, MDD was not significantly related to glycaemic changes. MDD had no significant effect on incident T2D (men: OR 1.58; 0.55, 4.52; women: OR 0.76; 0.37, 1.58).
Conclusions: Findings of the current study highlight the role of depression in T2D prevention, particularly among women.
(© 2021 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK.)
Methods: The study was based on a cohort of n = 1,766 adults without diabetes (776 men, 990 women; 18-65 years of age) who participated in the mental health supplement of the German National Health Interview and Examination Survey (GNHIES98-MHS, 1997-1999) and in a follow-up survey (DEGS1, 2008-2011). Glycaemic status was defined as normoglycaemia [HbA1c < 39 mmol/mol (<5.7%)], prediabetes [39 ≤ HbA1c < 48 mmol/mol (5.7-6.4%)] and diabetes [HbA1c ≥ 48 mmol/mol (≥ 6.5%), diagnosed diabetes, or antidiabetic medication], and glycaemic changes categorized as 'remission', 'stability' and 'progression'. Baseline MDD was assessed via a modified German version of the WHO Composite International Diagnostic Interview. Multivariable logistic regressions were applied to analyse the association of MDD with glycaemic changes and incident T2D, adjusting for socio-demographics, lifestyle conditions, chronic diseases, antidepressant use and mental health care.
Results: MDD prevalence was 21.4% for women and 8.9% for men. Among women, MDD was associated with a lower chance for remission (RRR 0.43; 95% CI 0.23, 0.82). Among men, MDD was not significantly related to glycaemic changes. MDD had no significant effect on incident T2D (men: OR 1.58; 0.55, 4.52; women: OR 0.76; 0.37, 1.58).
Conclusions: Findings of the current study highlight the role of depression in T2D prevention, particularly among women.
(© 2021 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK.)