학술논문
The Shortening of MWNT-SPION Hybrids by Steam Treatment Improves Their Magnetic Resonance Imaging Properties In Vitro and In Vivo.
Document Type
Academic Journal
Author
Cabana L; Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus UAB, 08193, Bellaterra, Barcelona, Spain.; Bourgognon M; Institute of Pharmaceutical Science, King's College London, London, SE1 9NH, UK.; Wang JT; Institute of Pharmaceutical Science, King's College London, London, SE1 9NH, UK.; Protti A; Division of Imaging Sciences and Biomedical Engineering, King's College London, St. Thomas' Hospital, London, SE1 7EH, UK.; Cardiovascular Division, James Black Centre, British Heart Foundation Centre of Excellence, King's College London, London, SE5 9NU, UK.; Klippstein R; Institute of Pharmaceutical Science, King's College London, London, SE1 9NH, UK.; de Rosales RT; Division of Imaging Sciences and Biomedical Engineering, King's College London, St. Thomas' Hospital, London, SE1 7EH, UK.; Shah AM; Cardiovascular Division, James Black Centre, British Heart Foundation Centre of Excellence, King's College London, London, SE5 9NU, UK.; Fontcuberta J; Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus UAB, 08193, Bellaterra, Barcelona, Spain.; Tobías-Rossell E; Escola Universitària de Ciències de la Salut de Manresa, Universitat de Vic-Universitat Central de Catalunya, Av. Universitària 4-6, 08242, Manresa, Barcelona, Spain.; Sosabowski JK; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, EC1A 7BE, UK.; Al-Jamal KT; Institute of Pharmaceutical Science, King's College London, London, SE1 9NH, UK.; Tobias G; Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus UAB, 08193, Bellaterra, Barcelona, Spain.
Source
Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101235338 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1613-6829 (Electronic) Linking ISSN: 16136810 NLM ISO Abbreviation: Small Subsets: MEDLINE
Subject
Language
English
Abstract
Carbon nanotubes (CNTs) have been advocated as promising nanocarriers in the biomedical field. Their high surface area and needle-like shape make these systems especially attractive for diagnostic and therapeutic applications. Biocompatibility, cell internalization, biodistribution, and pharmacokinetic profile have all been reported to be length dependent. In this study, further insights are gotten on the role that the length of CNTs plays when developing novel contrast agents for magnetic resonance imaging (MRI). Two samples of CNTs with different length distribution have been decorated with radio-labeled iron oxide nanoparticles. Despite characterization of the prepared hybrids reveals a similar degree of loading and size of the nanoparticles for both samples, the use of short CNTs is found to enhance the MRI properties of the developed contrast agents both in vitro and in vivo compared to their long counterparts.
(© 2016 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
(© 2016 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)