학술논문
The Association of HLA-B*35 and GSTT1 Genotypes and Hepatotoxicity in Thai People Living with HIV.
Document Type
Academic Journal
Author
Chanhom N; Department of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.; Jittikoon J; Department of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.; Wattanapokayakit S; Genomic Medicine Centre, Division of Genomic Medicine and Innovation Support, Department of Medical Sciences, Ministry of Public Health, Nonthaburi 11000, Thailand.; Mahasirimongkol S; Genomic Medicine Centre, Division of Genomic Medicine and Innovation Support, Department of Medical Sciences, Ministry of Public Health, Nonthaburi 11000, Thailand.; Charoenyingwattana A; Genomic Medicine Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.; Udomsinprasert W; Department of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.; Chaikledkaew U; Social Administrative Pharmacy Division, Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.; Suvichapanich S; Department of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.; Mushiroda T; Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.; Kiertiburanakul S; Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.; Rojanawiwat A; Clinical Research Center, Department of Medical Sciences, Ministry of Public Health, Nonthaburi 11000, Thailand.; Wangsomboonsiri W; Department of Internal Medicine, Sawanpracharak Hospital, Nakornsawan 60000, Thailand.; Manosuthi W; Internal Medicine, Bamrasnaradura Infectious Diseases Institute, Nonthaburi 11000, Thailand.; Kantipong P; Department of Internal Medicine, Chiangrai Prachanukroh Hospital, Chiang Rai 57000, Thailand.; Apisarnthanarak A; Division of Infectious Diseases, Department of Medicine, Thammasat University Hospital, Pathum Thani 12121, Thailand.; Sangsirinakakul W; Internal Medicine, Maharaj Nakorn Ratchasima Hospital, Nakorn Ratchasima 30000, Thailand.; Wongprasit P; Internal Medicine, Buriram Hospital, Buri Ram 31000, Thailand.; Chaiwarith R; Department of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.; Tantisiriwat W; Department of Preventive Medicine and Social Medicine, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand.; Sungkanuparph S; Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samut Prakan 10540, Thailand.; Chantratita W; Genomic Medicine Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
Source
Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101602269 Publication Model: Electronic Cited Medium: Print ISSN: 2075-4426 (Print) Linking ISSN: 20754426 NLM ISO Abbreviation: J Pers Med Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
2075-4426
Abstract
Glutathione s-transferase (GST) is a family of drug-metabolizing enzymes responsible for metabolizing and detoxifying drugs and xenobiotic substances. Therefore, deletion polymorphisms of GST s can be implicated in developing several pathological conditions, including antiretroviral drug-induced liver injury (ARVDILI). Notably, GST polymorphisms have been shown to be associated with ARVDILI risk. However, data on GST polymorphisms in the Thai population are limited. Therefore, this study investigated possible associations between GST genetic polymorphisms and ARVDILI development. A total of 362 people living with HIV (PLHIV) and 85 healthy controls from multiple centers were enrolled. GSTM1 and GSTT1 genetic polymorphisms were determined using polymerase chain reactions. In addition, HLA genotypes were determined using a sequence-based HLA typing method. After comparing GST genotypic frequencies, there was no significant difference between PLHIV and healthy volunteers. However, while observing the PLHIV group, GSTT1 wild type was significantly associated with a 2.04-fold increased risk of ARVDILI (95%CI: 1.01, 4.14; p = 0.045). Interestingly, a combination of GSTT1 wild type and HLA-B*35:05 was associated with a 2.28-fold higher risk of ARVDILI (95%CI: 1.15, 4.50; p = 0.02). Collectively, GSTT1 wild type and a combination of GSTT1 wild type plus HLA-B*35:05 were associated with susceptibility to ARVDILI in the Thai population.