학술논문
Apoptotic Bodies of Cardiomyocytes and Fibroblasts - Regulators of Directed Differentiation of Heart Stem Cells.
Document Type
Academic Journal
Author
Tyukavin AI; St. Petersburg State Chemical Pharmaceutical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia. atuykavin@mail.ru.; Belostotskaya GB; I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.; Zakharov ЕА; St. Petersburg State Chemical Pharmaceutical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia.; Ivkin DY; St. Petersburg State Chemical Pharmaceutical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia.; Rad'ko SV; St. Petersburg State Chemical Pharmaceutical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia.; Knyazev NA; St. Petersburg Clinical Research and Practical Center of Specialized Types of Medical Care (Oncologic), St. Petersburg, Russia.; Klimenko VV; St. Petersburg Clinical Research and Practical Center of Specialized Types of Medical Care (Oncologic), St. Petersburg, Russia.; Bogdanov AA; St. Petersburg Clinical Research and Practical Center of Specialized Types of Medical Care (Oncologic), St. Petersburg, Russia.; Suchkov SV; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
Source
Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-8221 (Electronic) Linking ISSN: 00074888 NLM ISO Abbreviation: Bull Exp Biol Med Subsets: MEDLINE
Subject
Language
English
Abstract
We studied the effects of apoptotic bodies of cardiomyocytes (ApBc) and fibroblasts (ApBf) on myocardial regeneration and contractility in rats and the dynamics of RNA concentrations in cardiomyocytes and fibroblasts at different stages of apoptosis. ApBc increase the contractility of rat myocardium, while ApBf reduce it. ApBc stimulate the development of clones of cardiomyocyte precursors in the myocardium, while ApBf stimulate the formation of endothelial precursor clones. In doxorubicin cardiomyopathy, ApBc, similar to the reference drug (ACE inhibitor) improve animal survival, while ApBf produce no such effect. RNA concentrations in cardiomyocytes and fibroblasts before apoptosis and at the beginning of cell death significantly differed, while in apoptotic bodies of these cells, it was practically the same. It has been hypothesized that RNA complex present in ApBc and ApBf represents an "epigenetic code" of directed differentiation of cardiac stem cells.