학술논문
Post-administration dosimetry in yttrium-90 radioembolization through micro-CT imaging of radiopaque microspheres in a porcine renal model.
Document Type
Academic Journal
Author
Henry EC; Department of Physics and Atmospheric Science, Dalhousie University, Halifax, Canada.; Strugari M; Department of Physics and Atmospheric Science, Dalhousie University, Halifax, Canada.; Biomedical Translational Imaging Centre, Halifax, Canada.; Mawko G; Department of Physics and Atmospheric Science, Dalhousie University, Halifax, Canada.; Department of Diagnostic Radiology, Dalhousie University, Halifax, Canada.; Department of Medical Physics, Nova Scotia Health Authority, Halifax, Canada.; Department of Radiation Oncology, Dalhousie University, Halifax, Canada.; Brewer KD; Department of Physics and Atmospheric Science, Dalhousie University, Halifax, Canada.; Biomedical Translational Imaging Centre, Halifax, Canada.; Department of Diagnostic Radiology, Dalhousie University, Halifax, Canada.; Department of Biomedical Engineering, Dalhousie University, Halifax, Canada.; Abraham R; Department of Diagnostic Radiology, Dalhousie University, Halifax, Canada.; ABK Biomedical Inc., Halifax, Canada.; Kappadath SC; Department of Imaging Physics, University of Texas MD Anderson Cancer Centre, Houston, United States of America.; Syme A; Department of Physics and Atmospheric Science, Dalhousie University, Halifax, Canada.; Department of Medical Physics, Nova Scotia Health Authority, Halifax, Canada.; Department of Radiation Oncology, Dalhousie University, Halifax, Canada.
Source
Publisher: IOP Publishing Country of Publication: England NLM ID: 0401220 Publication Model: Electronic Cited Medium: Internet ISSN: 1361-6560 (Electronic) Linking ISSN: 00319155 NLM ISO Abbreviation: Phys Med Biol Subsets: MEDLINE
Subject
Language
English
Abstract
The purpose of this study is to perform post-administration dosimetry in yttrium-90 radioembolization through micro-CT imaging of radiopaque microsphere distributions in a porcine renal model and explore the impact of spatial resolution of an imaging system on the extraction of specific dose metrics. Following the administration of radiopaque microspheres to the kidney of a hybrid farm pig, the kidney was explanted and imaged with micro-CT. To produce an activity distribution, 400 MBq of yttrium-90 activity was distributed throughout segmented voxels of the embolized vasculature based on an established linear relationship between microsphere concentration and CT voxel value. This distribution was down-sampled to coarser isotropic grids ranging in voxel size from 2.5 to 15 mm to emulate nominal resolutions comparable to those found in yttrium-90 PET and Bremsstrahlung SPECT imaging. Dose distributions were calculated through the convolution of activity distributions with dose-voxel kernels generated using the GATE Monte Carlo toolkit. Contours were computed to represent normal tissue and target volumes. Dose-volume histograms, dose metrics, and dose profiles were compared to a ground truth dose distribution computed with GATE. The mean dose to the target for all studied voxel sizes was found to be within 5.7% of the ground truth mean dose.D70was shown to be strongly correlated with image voxel size of the dose distribution ( r 2 = 0.90).D70is cited in the literature as an important dose metric and its dependence on voxel size suggests higher resolution dose distributions may provide new perspectives on dose-response relationships in yttrium-90 radioembolization. This study demonstrates that dose distributions with large voxels incorrectly homogenize the dose by attributing escalated doses to normal tissues and reduced doses in high-dose target regions. High-resolution micro-CT imaging of radiopaque microsphere distributions can provide increased confidence in characterizing the absorbed dose heterogeneity in yttrium-90 radioembolization.
(© 2021 Institute of Physics and Engineering in Medicine.)
(© 2021 Institute of Physics and Engineering in Medicine.)