학술논문
Concomitant necrotizing encephalitis and granulomatous meningoencephalitis in four toy breed dogs.
Document Type
Report
Author
Nessler JN; Department for Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany.; Oevermann A; Department of Clinical Research and Veterinary Public Health, Vetsuisse Faculty, University of Bern, Bern, Switzerland.; Schawacht M; Department for Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany.; Gerhauser I; Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany.; Spitzbarth I; Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany.; Bittermann S; Department of Clinical Research and Veterinary Public Health, Vetsuisse Faculty, University of Bern, Bern, Switzerland.; Steffen F; Department of Clinical Neurology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.; Schmidt MJ; Clinic for Small Animal-Surgery, Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Justus-Liebig-University, Giessen, Germany.; Tipold A; Department for Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany.
Source
Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101666658 Publication Model: eCollection Cited Medium: Print ISSN: 2297-1769 (Print) Linking ISSN: 22971769 NLM ISO Abbreviation: Front Vet Sci Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
2297-1769
Abstract
The term "meningoencephalitis of unknown origin" (MUO) describes a group of different encephalitides in dogs in which no infectious agent can be identified and a multifactorial etiology is suspected. Among others, genetic factors and unknown triggers seem to be involved. Included are necrotizing leukoencephalitis (NLE), necrotizing meningoencephalitis (NME), and granulomatous meningoencephalitis (GME). In this case series, we describe the histopathological findings of four toy breed dogs with focal or multifocal necrotizing encephalitis and mainly lymphocytic perivascular infiltrates on histopathological examination. At the same time, however, in all dogs, focal or multifocal high-grade angiocentric granulomatous inflammatory lesions were evident with focal histiocytic perivascular infiltrates in the brain. The former changes are typical for NLE and NME. In contrast, the latter changes are indicative of GME. This case series shows that the boundaries between the necrotizing and granulomatous variants of MUO might be smooth and suggests that NLE, NME, and GME are not as distinct as previously described. This finding could be a crucial piece of the puzzle in the study of the pathogenesis of MUO as individual susceptibility and specific triggers could be responsible for the manifestation of the different MUO subtypes.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Nessler, Oevermann, Schawacht, Gerhauser, Spitzbarth, Bittermann, Steffen, Schmidt and Tipold.)
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Nessler, Oevermann, Schawacht, Gerhauser, Spitzbarth, Bittermann, Steffen, Schmidt and Tipold.)