학술논문
Cerebellar and thalamic connector hubs facilitate the involvement of visual and cognitive networks in essential tremor.
Document Type
Academic Journal
Author
Bagarinao E; Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan; Brain and Mind Research Center, Nagoya University, Nagoya, Aichi, Japan. Electronic address: ebagarinao@met.nagoya-u.ac.jp.; Maesawa S; Brain and Mind Research Center, Nagoya University, Nagoya, Aichi, Japan; Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.; Kato S; Focused Ultrasound Therapy Center, Nagoya Kyoritsu Hospital, Nagoya, Aichi, Japan.; Mutoh M; Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.; Ito Y; Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.; Ishizaki T; Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.; Tanei T; Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.; Tsuboi T; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.; Suzuki M; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.; Watanabe H; Brain and Mind Research Center, Nagoya University, Nagoya, Aichi, Japan; Department of Neurology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.; Hoshiyama M; Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan; Brain and Mind Research Center, Nagoya University, Nagoya, Aichi, Japan.; Isoda H; Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan; Brain and Mind Research Center, Nagoya University, Nagoya, Aichi, Japan.; Katsuno M; Brain and Mind Research Center, Nagoya University, Nagoya, Aichi, Japan; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan; Department of Clinical Research Education, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.; Sobue G; Brain and Mind Research Center, Nagoya University, Nagoya, Aichi, Japan; Aichi Medical University, Nagakute, Aichi, Japan.; Saito R; Brain and Mind Research Center, Nagoya University, Nagoya, Aichi, Japan; Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Source
Publisher: Elsevier Science Country of Publication: England NLM ID: 9513583 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5126 (Electronic) Linking ISSN: 13538020 NLM ISO Abbreviation: Parkinsonism Relat Disord Subsets: MEDLINE
Subject
Language
English
Abstract
Introduction: Connector hubs are specialized brain regions that connect multiple brain networks and therefore have the potential to affect the functions of multiple systems. This study aims to examine the involvement of connector hub regions in essential tremor.
Methods: We examined whole-brain functional connectivity alterations across multiple brain networks in 27 patients with essential tremor and 27 age- and sex-matched healthy controls to identify affected hub regions using a network metric called functional connectivity overlap ratio estimated from resting-state functional MRI. We also evaluated the relationships of affected hubs with cognitive and tremor scores in all patients and with motor function improvement scores in 15 patients who underwent postoperative follow-up evaluations after focused ultrasound thalamotomy.
Results: We have identified affected connector hubs in the cerebellum and thalamus. Specifically, the dentate nucleus in the cerebellum and the dorsomedial thalamus exhibited more extensive connections with the sensorimotor network in patients. Moreover, the connections of the thalamic pulvinar with the visual network were also significantly widespread in the patient group. The connections of these connector hub regions with cognitive networks were negatively associated (FDR q < 0.05) with cognitive, tremor, and motor function improvement scores.
Conclusion: In patients with essential tremor, connector hub regions within the cerebellum and thalamus exhibited widespread functional connections with sensorimotor and visual networks, leading to alternative pathways outside the classical tremor axis. Their connections with cognitive networks also affect patients' cognitive function.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Gen Sobue reports a relationship with Mitsubishi Tanabe Pharma Corporation that includes: paid expert testimony and speaking and lecture fees. Gen Sobue reports a relationship with Cyberdine, Inc that includes: speaking and lecture fees. Gen Sobue reports a relationship with Takeda Pharmaceutical Company Limited that includes: paid expert testimony and speaking and lecture fees. Gen Sobue reports a relationship with Biogen Japan Ltd that includes: paid expert testimony. Ryuta Saito reports a relationship with Idorsia Pharmaceuticals Japan Co Ltd that includes: funding grants. Ryuta Saito reports a relationship with Kaneka Corporation that includes: funding grants. Ryuta Saito reports a relationship with Eisai Inc that includes: speaking and lecture fees. Ryuta Saito reports a relationship with Daiichi Sankyo Co Ltd Tokyo that includes: speaking and lecture fees. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Methods: We examined whole-brain functional connectivity alterations across multiple brain networks in 27 patients with essential tremor and 27 age- and sex-matched healthy controls to identify affected hub regions using a network metric called functional connectivity overlap ratio estimated from resting-state functional MRI. We also evaluated the relationships of affected hubs with cognitive and tremor scores in all patients and with motor function improvement scores in 15 patients who underwent postoperative follow-up evaluations after focused ultrasound thalamotomy.
Results: We have identified affected connector hubs in the cerebellum and thalamus. Specifically, the dentate nucleus in the cerebellum and the dorsomedial thalamus exhibited more extensive connections with the sensorimotor network in patients. Moreover, the connections of the thalamic pulvinar with the visual network were also significantly widespread in the patient group. The connections of these connector hub regions with cognitive networks were negatively associated (FDR q < 0.05) with cognitive, tremor, and motor function improvement scores.
Conclusion: In patients with essential tremor, connector hub regions within the cerebellum and thalamus exhibited widespread functional connections with sensorimotor and visual networks, leading to alternative pathways outside the classical tremor axis. Their connections with cognitive networks also affect patients' cognitive function.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Gen Sobue reports a relationship with Mitsubishi Tanabe Pharma Corporation that includes: paid expert testimony and speaking and lecture fees. Gen Sobue reports a relationship with Cyberdine, Inc that includes: speaking and lecture fees. Gen Sobue reports a relationship with Takeda Pharmaceutical Company Limited that includes: paid expert testimony and speaking and lecture fees. Gen Sobue reports a relationship with Biogen Japan Ltd that includes: paid expert testimony. Ryuta Saito reports a relationship with Idorsia Pharmaceuticals Japan Co Ltd that includes: funding grants. Ryuta Saito reports a relationship with Kaneka Corporation that includes: funding grants. Ryuta Saito reports a relationship with Eisai Inc that includes: speaking and lecture fees. Ryuta Saito reports a relationship with Daiichi Sankyo Co Ltd Tokyo that includes: speaking and lecture fees. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)