학술논문
Bariatric Surgery Leads to a Reduction in Antibodies to Apolipoprotein A-1: a Prospective Cohort Study.
Document Type
Academic Journal
Author
Adam S; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK.; Department of Endocrinology, The Christie NHS Foundation Trust, Manchester, M20 4BX, UK.; Ho JH; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK.; Department of Endocrinology, The Christie NHS Foundation Trust, Manchester, M20 4BX, UK.; Liu Y; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK.; Siahmansur T; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK.; Iqbal Z; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK.; Cardiovascular Trials Unit, Manchester University NHS Foundation Trust, Manchester, M13 9WL, UK.; Pagano S; Division of Laboratory Medicine, Diagnostic Department, Geneva University Hospital, 1205, Geneva, Switzerland.; Department of Internal Medicine Specialities, Medical Faculty, Geneva University, 1205, Geneva, Switzerland.; Azmi S; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK.; Cardiovascular Trials Unit, Manchester University NHS Foundation Trust, Manchester, M13 9WL, UK.; Dhage SS; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK.; Department of Endocrinology, The Christie NHS Foundation Trust, Manchester, M20 4BX, UK.; Donn R; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK.; Ammori BJ; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK.; Department of Diabetes, Endocrinology and Obesity Medicine, Salford Royal NHS Foundation Trust, Salford, M6 8HD, UK.; Syed AA; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK.; Department of Diabetes, Endocrinology and Obesity Medicine, Salford Royal NHS Foundation Trust, Salford, M6 8HD, UK.; Durrington PN; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK.; Malik RA; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK.; Department of Medicine, Weill Cornell Medicine-Qatar, 24144, Doha, Qatar.; Vuilleumier N; Division of Laboratory Medicine, Diagnostic Department, Geneva University Hospital, 1205, Geneva, Switzerland.; Department of Internal Medicine Specialities, Medical Faculty, Geneva University, 1205, Geneva, Switzerland.; Soran H; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK. handrean.soran@mft.nhs.uk.; Cardiovascular Trials Unit, Manchester University NHS Foundation Trust, Manchester, M13 9WL, UK. handrean.soran@mft.nhs.uk.
Source
Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 9106714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1708-0428 (Electronic) Linking ISSN: 09608923 NLM ISO Abbreviation: Obes Surg Subsets: MEDLINE
Subject
Language
English
Abstract
Purpose: Autoantibodies against apolipoprotein A-1 have been associated with cardiovascular disease, poorer CV outcomes and all-cause mortality in obese individuals. The impact of bariatric surgery (BS) on the presence of circulating anti-apoA-1 IgG antibodies is unknown. This study aimed to determine the effect of bariatric surgery on auto-antibodies titres against Apolipoprotein A-1 (anti-apoA-1 IgG), looking for changes associated with lipid parameters, insulin resistance, inflammatory profile and percentage of excess body mass index loss (%EBMIL).
Materials and Methods: We assessed 55 patients (40 women) before, 6 and 12 months post-operatively. Baseline and post-operative clinical history and measurements of body mass index (BMI), serum cholesterol, triglycerides, high- and low-density lipoprotein cholesterol (HDL-C and LDL-C), apoA-1, highly sensitive C-reactive protein (hsCRP), fasting glucose (FG), glycated haemoglobin (HbA1c) and HOMA-IR were taken at each point. Human anti-apoA-1 IgG were measured by ELISA.
Results: The mean age of participants was 50 years. BS significantly improved BMI, %EBMIL triglycerides, HDL-C, apoA-1, hsCRP, HBA1c, FG and HOMA-IR. Baseline anti-apoA-1 IgG seropositivity was 25% and was associated with lower apoA-1 and higher hsCRP levels. One year after BS, anti-apoA-1 IgG seropositivity decreased to 15% (p = 0.007) and median anti-apoA-1 IgG values decreased from 0.70 (0.56-0.84) to 0.47 (0.37-0.61) AU (p < 0.001). Post-operative anti-apoA-1 IgG levels were significantly associated with a decreased post-surgical %EBMIL at 1 year.
Conclusion: Bariatric surgery results in significant reduction in anti-apoA-1 IgG levels, which may adversely influence weight loss. The exact mechanisms underpinning these results are elusive and require further study before defining any clinical recommendations.
(© 2021. The Author(s).)
Materials and Methods: We assessed 55 patients (40 women) before, 6 and 12 months post-operatively. Baseline and post-operative clinical history and measurements of body mass index (BMI), serum cholesterol, triglycerides, high- and low-density lipoprotein cholesterol (HDL-C and LDL-C), apoA-1, highly sensitive C-reactive protein (hsCRP), fasting glucose (FG), glycated haemoglobin (HbA1c) and HOMA-IR were taken at each point. Human anti-apoA-1 IgG were measured by ELISA.
Results: The mean age of participants was 50 years. BS significantly improved BMI, %EBMIL triglycerides, HDL-C, apoA-1, hsCRP, HBA1c, FG and HOMA-IR. Baseline anti-apoA-1 IgG seropositivity was 25% and was associated with lower apoA-1 and higher hsCRP levels. One year after BS, anti-apoA-1 IgG seropositivity decreased to 15% (p = 0.007) and median anti-apoA-1 IgG values decreased from 0.70 (0.56-0.84) to 0.47 (0.37-0.61) AU (p < 0.001). Post-operative anti-apoA-1 IgG levels were significantly associated with a decreased post-surgical %EBMIL at 1 year.
Conclusion: Bariatric surgery results in significant reduction in anti-apoA-1 IgG levels, which may adversely influence weight loss. The exact mechanisms underpinning these results are elusive and require further study before defining any clinical recommendations.
(© 2021. The Author(s).)