학술논문
Chromatin organization of muscle stem cell.
Document Type
Academic Journal
Author
Santarelli P; INGM Istituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy.; Rosti V; INGM Istituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy; CNR Institute of Biomedical Technologies, Milan, Italy.; Vivo M; Università degli studi di Salerno, Fisciano, Italy. Electronic address: mvivo@unisa.it.; Lanzuolo C; INGM Istituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy; CNR Institute of Biomedical Technologies, Milan, Italy. Electronic address: chiara.lanzuolo@cnr.it.
Source
Publisher: Elsevier Country of Publication: United States NLM ID: 0163114 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8933 (Electronic) Linking ISSN: 00702153 NLM ISO Abbreviation: Curr Top Dev Biol Subsets: MEDLINE
Subject
Language
English
Abstract
The proper functioning of skeletal muscles is essential throughout life. A crucial crosstalk between the environment and several cellular mechanisms allows striated muscles to perform successfully. Notably, the skeletal muscle tissue reacts to an injury producing a completely functioning tissue. The muscle's robust regenerative capacity relies on the fine coordination between muscle stem cells (MuSCs or "satellite cells") and their specific microenvironment that dictates stem cells' activation, differentiation, and self-renewal. Critical for the muscle stem cell pool is a fine regulation of chromatin organization and gene expression. Acquiring a lineage-specific 3D genome architecture constitutes a crucial modulator of muscle stem cell function during development, in the adult stage, in physiological and pathological conditions. The context-dependent relationship between genome structure, such as accessibility and chromatin compartmentalization, and their functional effects will be analysed considering the improved 3D epigenome knowledge, underlining the intimate liaison between environmental encounters and epigenetics.
(Copyright © 2024. Published by Elsevier Inc.)
(Copyright © 2024. Published by Elsevier Inc.)