학술논문
Inflammation profile in overweight/obese adolescents in Europe: an analysis in relation to iron status.
Document Type
Academic Journal
Author
Ferrari M; CRA-NUT, Agricultural Research Council-Food and Nutrition Research Centre, Rome, Italy.; Cuenca-García M; Department of Medical Physiology, School of Medicine, Granada University, Granada, Spain.; Valtueña J; 1] CRA-NUT, Agricultural Research Council-Food and Nutrition Research Centre, Rome, Italy [2] ImFine Research Group, Department of Health and Human Performance, Facultad de Ciencias de la Actividad Fisica y del Deporte-INEF, Universidad Politécnica de Madrid, Madrid, Spain.; Moreno LA; 1] GENUD (Growth, Exercise, Nutrition and Development) research group, E.U. Ciencias de la Salud, Universidad de Zaragoza, Zaragoaza, Spain [2] Visiting Professor, School of Medicine of the University of São Paulo - Department of Preventive Medicine, São Paulo, Brazil.; Censi L; CRA-NUT, Agricultural Research Council-Food and Nutrition Research Centre, Rome, Italy.; González-Gross M; 1] ImFine Research Group, Department of Health and Human Performance, Facultad de Ciencias de la Actividad Fisica y del Deporte-INEF, Universidad Politécnica de Madrid, Madrid, Spain [2] Department of Nutrition and Food Sciences-Nutritional Physiology, University of Bonn, Bonn, Germany.; Androutsos O; Department of Nutrition and Dietetics, Harakopio University, Athens, Greece.; Gilbert CC; Department of Consumer & Sensory Sciences, Campden BRI, Gloucestershire, UK.; Huybrechts I; International Agency for research on Cancer (IARC), Dietary Exposure Assessment group, Lyon, France.; Dallongeville J; INSERM U744, Institut Pasteur de Lille, Univesité Lille Nord de France, Lille, France.; Sjöström M; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.; Molnar D; Department of Paediatrics, University of Pécs, Pécs-József A.7, Hungary.; De Henauw S; 1] Ghent University, Department of Public Health, University Hospital, Ghent, Belgium [2] University College Ghent, Department of Nutrition and Dietetics, Faculty of Health Care 'Vesalius', Ghent, Belgium.; Gómez-Martínez S; Immunonutrition Research Group, Department of Metabolism and Nutrition, Spanish Council for Scientific Research (CSIC), Madrid, Spain.; de Moraes AC; 1] GENUD (Growth, Exercise, Nutrition and Development) research group, E.U. Ciencias de la Salud, Universidad de Zaragoza, Zaragoaza, Spain [2] School of Medicine of the University of São Paulo - Post-Graduate Program in Science, Department of Preventive Medicine, São Paulo/SP, Brazil.; Kafatos A; Department of Social Medicine, Preventive Medicine and Nutrition Clinic, School of Medicine, University of Crete, Crete, Greece.; Widhalm K; Department of Paediatrics and Adolescents Medicine, Division of Clinical Nutrition, Private Medical University of Salzburg, Salzburg, Austria.; Leclercq C; CRA-NUT, Agricultural Research Council-Food and Nutrition Research Centre, Rome, Italy.
Source
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8804070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5640 (Electronic) Linking ISSN: 09543007 NLM ISO Abbreviation: Eur J Clin Nutr Subsets: MEDLINE
Subject
Language
English
Abstract
Background/objectives: The objectives of this study were to investigate the relationship between inflammatory parameters (CRP, c-reactive protein; AGP, α1-acid glycoprotein), iron status indicators (SF, serum ferritin; sTfR, soluble transferrin receptor) and body mass index (BMI) z-score, fat-free mass (FFM) and fat mass (FM) in European adolescents. Differences in intake for some nutrients (total iron, haem and non-haem iron, vitamin C, calcium, proteins) were assessed according to BMI categories, and the association of nutrient intakes with BMI z-score, FM and FFM was evaluated.
Methods: A total of 876 adolescents participating in the Healthy Lifestyle in Europe by Nutrition in Adolescence-Cross Sectional Study were included in the study sample.
Results: Mean CRP values (standard error; s.e.) were significantly higher in overweight/obese adolescents (1.7±0.3 and 1.4±0.3 mg/l in boys and girls, respectively) than in thin/normal-weight adolescents (1.1±0.2 and 1.0±0.1 mg/l in boys and girls, respectively) (P<0.05). For boys, mean SF values (s.e.) were significantly higher in overweight/obese adolescents (46.9±2.7 μg/l) than in thin/normal-weight adolescents (35.7±1.7 μg/l) (P<0.001), whereas median sTfR values did not differ among BMI categories for both boys and girls. Multilevel regression analyses showed that BMI z-score and FM were significantly related to CRP and AGP (P<0.05). Dietary variables did not differ significantly among BMI categories, except for the intake of vegetable proteins, which, for boys, was higher in thin/normal-weight adolescents than in overweight/obese adolescents (P<0.05).
Conclusions: The adiposity of the European adolescents was sufficient to cause chronic inflammation but not sufficient to impair iron status and cause iron deficiency.
Methods: A total of 876 adolescents participating in the Healthy Lifestyle in Europe by Nutrition in Adolescence-Cross Sectional Study were included in the study sample.
Results: Mean CRP values (standard error; s.e.) were significantly higher in overweight/obese adolescents (1.7±0.3 and 1.4±0.3 mg/l in boys and girls, respectively) than in thin/normal-weight adolescents (1.1±0.2 and 1.0±0.1 mg/l in boys and girls, respectively) (P<0.05). For boys, mean SF values (s.e.) were significantly higher in overweight/obese adolescents (46.9±2.7 μg/l) than in thin/normal-weight adolescents (35.7±1.7 μg/l) (P<0.001), whereas median sTfR values did not differ among BMI categories for both boys and girls. Multilevel regression analyses showed that BMI z-score and FM were significantly related to CRP and AGP (P<0.05). Dietary variables did not differ significantly among BMI categories, except for the intake of vegetable proteins, which, for boys, was higher in thin/normal-weight adolescents than in overweight/obese adolescents (P<0.05).
Conclusions: The adiposity of the European adolescents was sufficient to cause chronic inflammation but not sufficient to impair iron status and cause iron deficiency.