학술논문
Physical activity, sedentary time, and liver enzymes in adolescents: the HELENA study.
Document Type
Academic Journal
Author
Ruiz JR; 1] PROFITH 'PROmoting FITness and Health through physical activity' Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain [2] Department of Biosciences and Nutrition at NOVUM, Unit for Preventive Nutrition, Karolinska Institutet, Huddinge, Sweden.; Labayen I; 1] Department of Nutrition and Food Science, University of the Basque Country, Vitoria, Spain [2] GENUD 'Growth, Exercise, Nutrition and Development' Research Group, Zaragoza, Spain.; Ortega FB; 1] PROFITH 'PROmoting FITness and Health through physical activity' Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain [2] Department of Biosciences and Nutrition at NOVUM, Unit for Preventive Nutrition, Karolinska Institutet, Huddinge, Sweden.; Moreno LA; 1] GENUD 'Growth, Exercise, Nutrition and Development' Research Group, Zaragoza, Spain [2] Department of Health and Human Performance, School of Health Sciences, University of Zaragoza, Zaragoza, Spain.; Rodriguez G; 1] GENUD 'Growth, Exercise, Nutrition and Development' Research Group, Zaragoza, Spain [2] Department of Pediatrics, University of Zaragoza, Zaragoza, Spain.; Breidenassel C; Institut für Ernährungs und Lebensmittelwissenschaften - Humanernährung, Rheinische Friedrich-Wilhelms Universität Bonn, Bonn, Germany.; Manios Y; Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.; Kafatos A; Preventive Medicine and Nutrition Unit, School of Medicine, University of Crete, Crete, Greece.; Molnar D; Department of Pediatrics, University of Pecs, Pecs, Hungary.; De Henauw S; Department of Public Health, Ghent University, Ghent, Belgium.; Gottrand F; INSERM U995, Faculté de Médecine, University of Lille, Lille, France.; Widhalm K; Department of Pediatrics, Division of Clinical Nutrition, Medical University of Vienna, Vienna, Austria.; Castillo MJ; Department of Medical Physiology, School of Medicine, University of Granada, Granada, Spain.; Sjöström M; Department of Biosciences and Nutrition at NOVUM, Unit for Preventive Nutrition, Karolinska Institutet, Huddinge, Sweden.
Source
Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 0100714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0447 (Electronic) Linking ISSN: 00313998 NLM ISO Abbreviation: Pediatr Res Subsets: MEDLINE
Subject
Language
English
Abstract
Background: To examine the association between physical activity (PA) and liver enzyme levels in adolescents from nine European countries.
Methods: The study comprised 718 adolescents (397 girls). PA was measured by accelerometry and expressed as total PA (counts/min), and time (min/d) engaged in moderate to vigorous intensity PA (MVPA). Time spent sedentary was also objectively measured. We measured serum levels of alanine aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyltransferase (GGT), and the AST/ALT ratio was computed.
Results: There was an association between MVPA and AST and AST/ALT (age, sex, and center-adjusted β = 0.096, 95% confidence interval (CI): 0.016 to 0.118; and β = 0.090, 95% CI: 0.006 to 0.112, respectively). Meeting the PA recommendations (60 min/d of MVPA) was significantly associated with higher AST and AST/ALT, which persisted after further adjusting for sedentary time and waist circumference. Sedentary time was not associated with any of the studied liver enzyme levels.
Conclusion: Meeting the current PA recommendations of 60 min/d of MVPA is associated with higher levels of AST and AST/ALT regardless of time spent sedentary as well as total and central body fat in European adolescents.
Methods: The study comprised 718 adolescents (397 girls). PA was measured by accelerometry and expressed as total PA (counts/min), and time (min/d) engaged in moderate to vigorous intensity PA (MVPA). Time spent sedentary was also objectively measured. We measured serum levels of alanine aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyltransferase (GGT), and the AST/ALT ratio was computed.
Results: There was an association between MVPA and AST and AST/ALT (age, sex, and center-adjusted β = 0.096, 95% confidence interval (CI): 0.016 to 0.118; and β = 0.090, 95% CI: 0.006 to 0.112, respectively). Meeting the PA recommendations (60 min/d of MVPA) was significantly associated with higher AST and AST/ALT, which persisted after further adjusting for sedentary time and waist circumference. Sedentary time was not associated with any of the studied liver enzyme levels.
Conclusion: Meeting the current PA recommendations of 60 min/d of MVPA is associated with higher levels of AST and AST/ALT regardless of time spent sedentary as well as total and central body fat in European adolescents.