학술논문
The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes.
Document Type
Academic Journal
Author
Thorell K; Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden. kaisa.thorell@gu.se.; Muñoz-Ramírez ZY; Facultad de Ciencias Químicas, Universidad Autónoma de Chihuahua, Chihuahua, Chihuahua, México.; Wang D; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.; Sandoval-Motta S; Instituto Nacional de Medicina Genómica, Ciudad de México, México.; Consejo Nacional de Ciencia y Tecnologia, Cátedras CONACYT, Ciudad de México, México.; Centro de Ciencias de la Complejidad, Universidad Nacional Autónoma de México, Ciudad de México, México.; Boscolo Agostini R; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.; Ghirotto S; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.; Torres RC; Centre for Microbes Development and Health, Institute Pasteur Shanghai, Shanghai, China.; Falush D; Centre for Microbes Development and Health, Institute Pasteur Shanghai, Shanghai, China.; Camargo MC; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.; Rabkin CS; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Source
Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Subject
Language
English
Abstract
Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with differential gastric disease risk. Here, we provide insights into H. pylori population structure as a part of the Helicobacter pylori Genome Project (HpGP), a multi-disciplinary initiative aimed at elucidating H. pylori pathogenesis and identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from 50 countries and generated high-quality genome sequences. We analysed core genome diversity and population structure of the HpGP dataset and 255 worldwide reference genomes to outline the ancestral contribution to Eurasian, African, and American populations. We found evidence of substantial contribution of population hpNorthAsia and subpopulation hspUral in Northern European H. pylori. The genomes of H. pylori isolated from northern and southern Indigenous Americans differed in that bacteria isolated in northern Indigenous communities were more similar to North Asian H. pylori while the southern had higher relatedness to hpEastAsia. Notably, we also found a highly clonal yet geographically dispersed North American subpopulation, which is negative for the cag pathogenicity island, and present in 7% of sequenced US genomes. We expect the HpGP dataset and the corresponding strains to become a major asset for H. pylori genomics.
(© 2023. The Author(s).)
(© 2023. The Author(s).)