학술논문
Fused Cells between Human-Adipose-Derived Mesenchymal Stem Cells and Monocytes Keep Stemness Properties and Acquire High Mobility.
Document Type
Academic Journal
Author
Montalbán-Hernández K; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.; Tumour Immunology Lab, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.; Casado-Sánchez C; Department of Plastic and Reconstructive Surgery, University Hospital La Paz, 28046 Madrid, Spain.; Avendaño-Ortiz J; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.; Tumour Immunology Lab, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.; Centre for Biomedical Research Network of Respiratory Diseases (CIBERES), 28029 Madrid, Spain.; Casalvilla-Dueñas JC; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.; Tumour Immunology Lab, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.; Bonel-Pérez GC; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.; Tumour Immunology Lab, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.; Prado-Montero J; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.; Tumour Immunology Lab, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.; Valentín-Quiroga J; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.; Tumour Immunology Lab, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.; Lozano-Rodríguez R; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.; Tumour Immunology Lab, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.; Terrón-Arcos V; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.; Tumour Immunology Lab, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.; de la Bastida FR; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.; Tumour Immunology Lab, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.; Córdoba L; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.; Tumour Immunology Lab, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.; Biobank Platform, IdiPAZ, La Paz Universitary Hospital, 28046 Madrid, Spain.; Laso-García F; Neurological Sciences and Cerebrovascular Research Laboratory, Department of Neurology and Stroke Center, Neurology and Cerebrovascular Disease Group, Neuroscience Area La Paz Hospital Institute for Health Research-IdiPAZ, 28046 Madrid, Spain.; Diekhorst L; Neurological Sciences and Cerebrovascular Research Laboratory, Department of Neurology and Stroke Center, Neurology and Cerebrovascular Disease Group, Neuroscience Area La Paz Hospital Institute for Health Research-IdiPAZ, 28046 Madrid, Spain.; Del Fresno C; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.; Tumour Immunology Lab, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.; López-Collazo E; The Innate Immune Response Group, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.; Tumour Immunology Lab, IdiPAZ, La Paz University Hospital, 28046 Madrid, Spain.; Centre for Biomedical Research Network of Respiratory Diseases (CIBERES), 28029 Madrid, Spain.
Source
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
Subject
Language
English
Abstract
Human-adipose-derived mesenchymal stem cells (hADMSCs) are multipotent stem cells which have become of great interest in stem-cell therapy due to their less invasive isolation. However, they have limited migration and short lifespans. Therefore, understanding the mechanisms by which these cells could migrate is of critical importance for regenerative medicine. Methods: Looking for novel alternatives, herein, hADMSCs were isolated from adipose tissue and co-cultured with human monocytes ex vivo. Results: A new fused hybrid entity, a foam hybrid cell (FHC), which was CD90 + CD14 + , resulted from this co-culture and was observed to have enhanced motility, proliferation, immunomodulation properties, and maintained stemness features. Conclusions: Our study demonstrates the generation of a new hybrid cellular population that could provide migration advantages to MSCs, while at the same time maintaining stemness properties.