학술논문
Correlation between α-synuclein and fatty acid composition in jejunum of rotenone-treated mice is dependent on acyl chain length.
Document Type
Academic Journal
Author
Hajduchova D; Department of Pathological Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.; Holic R; Gajdos P; Certik M; Halasova E; Pecova R; Pokusa M
Source
Publisher: Ústav molekulárnej fyziológie a genetiky SAV Country of Publication: Slovakia NLM ID: 8400604 Publication Model: Print Cited Medium: Print ISSN: 0231-5882 (Print) Linking ISSN: 02315882 NLM ISO Abbreviation: Gen Physiol Biophys Subsets: MEDLINE
Subject
Language
English
ISSN
0231-5882
Abstract
Events associated with the progression of Parkinson´s disease (PD) are closely related to biomembrane dysfunction. The specific role of membrane composition in the conformational stability of alpha synuclein (αS) has already been well documented. Administration of rotenone is one of the best strategies to initiate PD phenotype in animal models. In the present study, daily exposure (14 weeks) of orally administered rotenone (10 mg/kg) was employed in a mouse model. The mitochondrial complex I inhibition resulted in elevated level of αS in whole tissue homogenate of mouse jejunum. In addition, we identified a strong intra-individual correlation between αS level and the specific esterified fatty acids. The observed correlation depends mainly on the acyl chain length. Based on the obtained results, it is suggested that there is a high potential to manipulate fatty acid homeostasis in modulating αS based pathogenesis of PD, at least in experimental conditions.