학술논문
Substrate characterization of the right ventricle in repaired tetralogy of Fallot using late enhancement cardiac magnetic resonance.
Document Type
Academic Journal
Author
Rivas-Gándara N; Arrhythmia Unit, Cardiology Department, Vall d'Hebron University Hospital, Barcelona, Spain; Faculty of Medicine and Surgery, Universitat Autonoma Barcelona (UAB), Barcelona, Spain; Vall d'Hebron Research Institute (VHIR), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain. Electronic address: nrivas@vhebron.net.; Dos-Subirá L; Faculty of Medicine and Surgery, Universitat Autonoma Barcelona (UAB), Barcelona, Spain; Vall d'Hebron Research Institute (VHIR), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; Integrated Congenital Heart Disease Unit, Vall d'Hebron University Hospital-Sant Pau Hospital, Barcelona, Spain.; Francisco-Pascual J; Arrhythmia Unit, Cardiology Department, Vall d'Hebron University Hospital, Barcelona, Spain; Faculty of Medicine and Surgery, Universitat Autonoma Barcelona (UAB), Barcelona, Spain; Vall d'Hebron Research Institute (VHIR), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain.; Rodríguez-García J; Arrhythmia Unit, Cardiology Department, Vall d'Hebron University Hospital, Barcelona, Spain; Faculty of Medicine and Surgery, Universitat Autonoma Barcelona (UAB), Barcelona, Spain; Vall d'Hebron Research Institute (VHIR), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain.; Pijuan-Domenech A; Faculty of Medicine and Surgery, Universitat Autonoma Barcelona (UAB), Barcelona, Spain; Vall d'Hebron Research Institute (VHIR), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; Integrated Congenital Heart Disease Unit, Vall d'Hebron University Hospital-Sant Pau Hospital, Barcelona, Spain.; Benito B; Arrhythmia Unit, Cardiology Department, Vall d'Hebron University Hospital, Barcelona, Spain; Faculty of Medicine and Surgery, Universitat Autonoma Barcelona (UAB), Barcelona, Spain; Vall d'Hebron Research Institute (VHIR), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain.; Valente F; Faculty of Medicine and Surgery, Universitat Autonoma Barcelona (UAB), Barcelona, Spain; Vall d'Hebron Research Institute (VHIR), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; Cardiac Imaging Unit, Cardiology Department, Vall d'Hebron University Hospital, Barcelona, Spain.; Pascual-González G; Arrhythmia Unit, Cardiology Department, Vall d'Hebron University Hospital, Barcelona, Spain.; Santos-Ortega A; Arrhythmia Unit, Cardiology Department, Vall d'Hebron University Hospital, Barcelona, Spain; Faculty of Medicine and Surgery, Universitat Autonoma Barcelona (UAB), Barcelona, Spain; Vall d'Hebron Research Institute (VHIR), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain.; Miranda B; Faculty of Medicine and Surgery, Universitat Autonoma Barcelona (UAB), Barcelona, Spain; Vall d'Hebron Research Institute (VHIR), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; Integrated Congenital Heart Disease Unit, Vall d'Hebron University Hospital-Sant Pau Hospital, Barcelona, Spain.; Pérez-Rodon J; Arrhythmia Unit, Cardiology Department, Vall d'Hebron University Hospital, Barcelona, Spain; Faculty of Medicine and Surgery, Universitat Autonoma Barcelona (UAB), Barcelona, Spain; Vall d'Hebron Research Institute (VHIR), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain.; Ribera-Solé A; Faculty of Medicine and Surgery, Universitat Autonoma Barcelona (UAB), Barcelona, Spain; Vall d'Hebron Research Institute (VHIR), Barcelona, Spain; Epidemiology Unit, Cardiology Department, Vall d'Hebron University Hospital, Barcelona, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Spain.; Burcet-Rodriguez G; Radiology Department (IDI), Vall d'Hebron University Hospital, Barcelona, Spain.; Roses-Noguer F; Arrhythmia Unit, Cardiology Department, Vall d'Hebron University Hospital, Barcelona, Spain; Faculty of Medicine and Surgery, Universitat Autonoma Barcelona (UAB), Barcelona, Spain; Vall d'Hebron Research Institute (VHIR), Barcelona, Spain; Department of Cardiology and Pediatric Cardiac Surgery, Vall d'Hebron University Hospital, Barcelona, Spain.; Gordon B; Faculty of Medicine and Surgery, Universitat Autonoma Barcelona (UAB), Barcelona, Spain; Vall d'Hebron Research Institute (VHIR), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; Integrated Congenital Heart Disease Unit, Vall d'Hebron University Hospital-Sant Pau Hospital, Barcelona, Spain.; Rodríguez-Palomares J; Faculty of Medicine and Surgery, Universitat Autonoma Barcelona (UAB), Barcelona, Spain; Vall d'Hebron Research Institute (VHIR), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; Cardiac Imaging Unit, Cardiology Department, Vall d'Hebron University Hospital, Barcelona, Spain.; Ferreira-González I; Faculty of Medicine and Surgery, Universitat Autonoma Barcelona (UAB), Barcelona, Spain; Vall d'Hebron Research Institute (VHIR), Barcelona, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Spain; Cardiology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
Source
Publisher: Elsevier Country of Publication: United States NLM ID: 101200317 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-3871 (Electronic) Linking ISSN: 15475271 NLM ISO Abbreviation: Heart Rhythm Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Three-dimensional (3D) substrate characterization by high-resolution late gadolinium enhancement cardiac magnetic resonance (LE-CMR) is useful for guiding ventricular tachycardia ablation of the left ventricle in ischemic heart disease.
Objective: The purpose of this study was to validate the substrate characterization and 3D reconstruction of LE-CMR images of the right ventricle (RV) in patients with repaired tetralogy of Fallot (rTOF) and to identify the algorithm that best fits with electroanatomic mapping (EAM).
Methods: RV LE-CMR images were compared with RV EAM in 10 patients with rTOF. RV LE-CMR images were postprocessed and analyzed to identify fibrotic tissue on 3D color maps. The 3D RV substrate reconstructions were created using an adjustable percentage of the maximum voxel signal intensity (MSI) of the scar region to define the threshold between core, transitional zone (TZ), and healthy tissue. Extensions of the core and TZ areas were compared with the scar (<0.5 mV) and low-voltage (0.5-1.5 mV) areas obtained by RV EAM. Agreement on anatomic isthmi identification was quantified.
Results: The best match between core and scar was obtained at 65% MSI cutoff (mean areas 17.4 ± 9.9 cm2 vs 16.9 ± 10.0 cm 2 , respectively; r = 0.954; P <.001). Agreement on anatomic isthmi identification was best at 60% MSI cutoff, which identified 95% of isthmi and achieved a total fit in 90% of patients.
Conclusion: This study demonstrates that characterization of the RV substrate by postprocessing LE-CMR images in rTOF patients is feasible and validates the technique against RV EAM, which could help in planning target ablation.
(Copyright © 2021 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)
Objective: The purpose of this study was to validate the substrate characterization and 3D reconstruction of LE-CMR images of the right ventricle (RV) in patients with repaired tetralogy of Fallot (rTOF) and to identify the algorithm that best fits with electroanatomic mapping (EAM).
Methods: RV LE-CMR images were compared with RV EAM in 10 patients with rTOF. RV LE-CMR images were postprocessed and analyzed to identify fibrotic tissue on 3D color maps. The 3D RV substrate reconstructions were created using an adjustable percentage of the maximum voxel signal intensity (MSI) of the scar region to define the threshold between core, transitional zone (TZ), and healthy tissue. Extensions of the core and TZ areas were compared with the scar (<0.5 mV) and low-voltage (0.5-1.5 mV) areas obtained by RV EAM. Agreement on anatomic isthmi identification was quantified.
Results: The best match between core and scar was obtained at 65% MSI cutoff (mean areas 17.4 ± 9.9 cm
Conclusion: This study demonstrates that characterization of the RV substrate by postprocessing LE-CMR images in rTOF patients is feasible and validates the technique against RV EAM, which could help in planning target ablation.
(Copyright © 2021 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)