학술논문
Efficacy of a new nutraceutical formulation: L-tryptophan, probiotics, charcoal, chamomile, mint, and licorice (COLONIR®) in the improvement of gastrointestinal symptoms in subjects with irritable bowel syndrome.
Document Type
Academic Journal
Author
Fiorini G; IRCCS University Hospital of Bologna, Bologna, Italy.; Saracino IM; Department of Surgical and Medical Sciences, University of Bologna, Bologna, Italy.; Pavoni M; Department of Surgical and Medical Sciences, University of Bologna, Bologna, Italy.; Nipote B; Unit of Surgery, Lagonegro Hospital, AOR S. Carlo, Potenza, Italy.; Colucci R; SC Foligno Hospital, USL Umbria2, Foligno, Perugia, Italy.; Capone P; Unit of Gastroenterology and Digestive Endoscopy, Maresca Hospital, Torre del Greco, Naples, Italy.; Sannino A; Unit of Gastroenterology and Digestive Endoscopy, Santa Maria della Pietà Hospital, Nola, Naples, Italy.; Forte F; UOSD of Interventional Gastroenterology, Madonna delle Grazie Hospital, Matera, Italy.; DE Vergori E; Unit of Gastroenterology and Digestive Endoscopy, G.B. Morgagni - L. Pierantoni Hospital, Forlì, Forlì-Cesena, Italy.; Brancaccio M; Unit of Gastroenterology and Digestive Endoscopy, S. Maria delle Croci Hospital, Ravenna, Italy.; Cesareo M; Unit of Gastroenterology, Tirrenia Hospital, Belvedere Marittimo, Cosenza, Italy.; Casella G; Private Practitioner in General Medicine - Gastroenterology, Monza, Monza-Brianza, Italy.; Morreale GC; Unit of Gastroenterology, Ospedali Riuniti S. Elia/Raimondi, Caltanissetta, Italy.; Bonfrate L; Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy.; Portincasa P; Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy.; Vincenzi M; Unit of Gastroenterology and Digestive Endoscopy, S. Pier Damiano Hospital, Faenza, Ravenna, Italy.; Cottone C; Private Practitioner in General Medicine - Gastroenterology, Palermo, Italy.; Ormando VM; Unit of Gastroenterology, San Giuseppe Moscati Hospital, Avellino, Italy.; Scalise N; Department of Digestive Endoscopy, ANMI Rossano Center, Cosenza, Italy.; Lawson PF; Unit of Gastroenterology and Digestive Endoscopy, Beato Matteo Clinical Institute, Vigevano, Pavia, Italy.; Burattini O; Unit of Gastroenterology II, IRCCS Saverio De Bellis, Castellana Grotte, Bari, Italy.; Montale A; Unit of Gastroenterology and Digestive Endoscopy, E.O. Ospedali Galliera, Genoa, Italy.; Luzza F; Unit of Pathophysiology of the Digestive System, Mater Domini Germaneto, Catanzaro, Italy.; Rossi M; Unit of Surgical Digestive Endoscopy, Civil Hospital of Avezzano, L'Aquila, Italy.; Vanni R; Section of Gastroenterology and Digestive Endoscopy, Michele e Pietro Ferrero Hospital, Cuneo, Italy.; Bozzi R; Unit of Gastroenterology and Digestive Endoscopy, ASL Benevento, Benevento, Italy.; Vincoli G; U.O.S.D Gastroenterology, San Camillo de Lellis Civil Hospital, Rieti, Italy.; Stefani N; Section of Gastroenterology, A.S.U. Giuliano Isontina, Trieste, Italy.; Borghi C; Department of Surgical and Medical Sciences, University of Bologna, Bologna, Italy.; Vaira D; Department of Surgical and Medical Sciences, University of Bologna, Bologna, Italy - berardino.vaira@unibo.it.
Source
Publisher: Minerva Medica Country of Publication: Italy NLM ID: 101777280 Publication Model: Print Cited Medium: Internet ISSN: 2724-5365 (Electronic) Linking ISSN: 27245985 NLM ISO Abbreviation: Minerva Gastroenterol (Torino) Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders. IBS is characterized by recurrent chronic abdominal pain and altered bowel habits in the absence of organic damage. Although there are reviews and guidelines for treating IBS, the complexity and diversity of IBS presentation make treatment difficult. Treatment of IBS focuses on relieving symptoms as mild signs and symptoms can often be controlled by managing stress and by making changes in diet and lifestyle. The use of nutraceutical compounds has been advocated as a possible alternative treatment in patients with IBS. COLONIR ® (Omega Pharma Srl, Milan, Italy) may be an alternative or adjuvant treatment in patients with gastrointestinal symptoms. This study aimed to evaluate the effect of this new nutraceutical formulation in inducing symptoms remission and improve gastrointestinal habits.
Methods: An initial cohort of 1004 consecutive patients referred to 25 different Units of Internal Medicine a/o Gastroenterology in Italy to perform colonoscopy for intestinal symptoms was asked to participate. Patients were treated for 2 months with two doses of nutraceuticals/day during meals namely COLONIR® . Patients were assessed at baseline and after 2 months to evaluate the frequency and severity of gastrointestinal symptoms in the past seven days with a questionnaire based on ROMA IV criteria.
Results: After 2 months, 899 patients completed the follow-up. COLONIR® achieved a statistically significant reduction of severity of symptoms in the study population without any documented side effects.
Conclusions: These promising results, here reported, need to be confirmed, valuating the efficacy of COLONIR® in relieving gastrointestinal symptoms in IBS patients in further studies.
Methods: An initial cohort of 1004 consecutive patients referred to 25 different Units of Internal Medicine a/o Gastroenterology in Italy to perform colonoscopy for intestinal symptoms was asked to participate. Patients were treated for 2 months with two doses of nutraceuticals/day during meals namely COLONIR
Results: After 2 months, 899 patients completed the follow-up. COLONIR
Conclusions: These promising results, here reported, need to be confirmed, valuating the efficacy of COLONIR