학술논문
The functional role of Nudt2 in human triple negative breast cancer.
Document Type
Academic Journal
Author
Abu-Rahmah R; Department of Oncology, Hadassah Hebrew University Medical Center, Jerusalem, Israel.; Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada, the Hebrew University of Jerusalem, Jerusalem, Israel.; Nechushtan H; Department of Oncology, Hadassah Hebrew University Medical Center, Jerusalem, Israel.; Hidmi S; Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada, the Hebrew University of Jerusalem, Jerusalem, Israel.; Meirovitz A; Department of Oncology, Soroka-Ben Gurion University Medical Center, Beer-Sheeva, Israel.; Razin E; Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada, the Hebrew University of Jerusalem, Jerusalem, Israel.; Peretz T; Department of Oncology, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Source
Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101568867 Publication Model: eCollection Cited Medium: Print ISSN: 2234-943X (Print) Linking ISSN: 2234943X NLM ISO Abbreviation: Front Oncol Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
2234-943X
Abstract
The main known function of Nudix hydrolase 2 (Nudt2) is to hydrolyze the secondary messenger diadenosine 5', 5'''-p1, p4-tetraphosphate (Ap4A). In this study we examined the role of Nudt2 in breast carcinoma through its expression in human invasive ductal carcinoma tissues, and its functions in human triple negative breast cancer (TNBC) cell lines. A significantly higher expression of Nudt2 was observed in human invasive ductal carcinoma tissues compared to that in normal breast tissue. Knockdown of Nudt2 in TNBC cell lines resulted in a significant reduction in cellular proliferation via the Ki67 marker, accompanied by G0/G1 phase cell cycle arrest, in the migration and invasion of these cells and in tumorigenicity and anchorage-independent growth. It can therefore be concluded that Nudt2 plays a significant role in promoting TNBC growth.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2024 Abu-Rahmah, Nechushtan, Hidmi, Meirovitz, Razin and Peretz.)
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2024 Abu-Rahmah, Nechushtan, Hidmi, Meirovitz, Razin and Peretz.)