학술논문
Eslicarbazepine acetate and carotid intima-media thickness in epileptic patients.
Document Type
Academic Journal
Author
Serrano-Castro PJ; Hospital Regional Universitario de Málaga, Neurology, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain.. Electronic address: pedro.serrano.c@gmail.com.; Fernández-Pérez J; Complejo Hospitalario Torrecardenas, Neurology, Almería, Spain.; López-González FJ; Complejo Hospitalario Universitario Santiago, Neurology, Santiago de Compostela, Spain.; Toledo-Argany M; Hospital Vall d'Hebron, Neurology, Barcelona, Spain.; Estévez-María JC; Hospital Universitario Reina Sofía, Neurology, Córdoba, Spain.; Arjona-Padillo A; Complejo Hospitalario Torrecardenas, Neurology, Almería, Spain.; Bertol-Alegre V; Hospital Universitario Miguel Servet, Neurology, Zaragoza, Spain.; Mauri-Llerda JA; Hospital Clinico Universitario Lozano Blesa, Neurology, Zaragoza, Spain.; Tortosa-Conesa D; Hospital Universitario Virgen de la Arrixaca, Neurology, Murcia, Spain.; Ruiz-Giménez J; Complejo Hospitalario de Granada, Neurology, Granada, Spain.; Querol-Pascual R; Hospital de Badajoz, Neurology, Badajoz, Spain.; García-Martínez A; Hospital Central de Asturias, Neurology, Oviedo, Spain.; Molto-Jorda JM; Hospital Virgen de los Lirios, Neurology, Alcoy, Spain.; Payán-Ortiz M; Complejo Hospitalario de Granada, Neurology, Granada, Spain.; Maestre-Moreno JF; Complejo Hospitalario de Granada, Neurology, Granada, Spain.; Galván-Espinosa J; Complejo Hospitalario Torrecárdenas, Fundación Investigación Biosanitaria Andalucía Oriental (FIBAO), Almería, Spain.
Source
Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8703089 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6844 (Electronic) Linking ISSN: 09201211 NLM ISO Abbreviation: Epilepsy Res Subsets: MEDLINE
Subject
Language
English
Abstract
Objective: Evaluate if eslicarbazepine acetate (ESL) in combination with other non-inducer antiepileptic drugs (AEDs) in the treatment of epilepsy may represent a positive impact in the cardiovascular risk profile.
Methods: multicentre, retrospective, observational, non-interventional, real-life study comparing patients treated with cytochrome P450 (CYP) inducer vs. ESL plus non-inducer AEDs. Primary endpoint: Carotid intima-media thickness (CIMT) measured following the Manheim Consensus criteria.
Results: Patients included: 163. The main demographic, clinical and vascular risk parameters were comparable between the two groups except for duration of the disease, prevalence of dyslipidemia and use of lipid-lowering drugs (significantly higher in the inducers group) and number of previous antiepileptic drugs (significantly higher in the non-inducers group). Bivariate analysis of the main endpoint showed almost significant differences (p=0.05) in CIMT measures favourable to non-inducers (average 0.617mm+SD=0.148) vs. inducers (average 0.663mm+SD=0.147). Other variables reaching statistical significance were: age >50 years (p<0.001), high blood pressure (p<0.01) and dyslipidemia (p<0.05). A multivariate analysis including these variables and biochemical vascular risk factors showed a predictor model including two variables: inducers group (p=0.031; Coefficient β=0.234) and age >50 years (p=0.001; Coefficient β=0.387). Regarding gender, the mean CIMT in males was significantly higher in the inducers (0.693mm; SD=0.139) than in the non- inducers groups (0.628mm; SD=0.151; p<0.05). In females the differences were not significant.
Significance: The use of CYP inducer AEDs is associated with a significant increase in CIMT as compared with ESL and other non-inducer AEDs. The study shows a decrease in the vascular risk measured by ultrasound criteria in male patients treated with ESL compared with patients treated with inducer AEDs.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Methods: multicentre, retrospective, observational, non-interventional, real-life study comparing patients treated with cytochrome P450 (CYP) inducer vs. ESL plus non-inducer AEDs. Primary endpoint: Carotid intima-media thickness (CIMT) measured following the Manheim Consensus criteria.
Results: Patients included: 163. The main demographic, clinical and vascular risk parameters were comparable between the two groups except for duration of the disease, prevalence of dyslipidemia and use of lipid-lowering drugs (significantly higher in the inducers group) and number of previous antiepileptic drugs (significantly higher in the non-inducers group). Bivariate analysis of the main endpoint showed almost significant differences (p=0.05) in CIMT measures favourable to non-inducers (average 0.617mm+SD=0.148) vs. inducers (average 0.663mm+SD=0.147). Other variables reaching statistical significance were: age >50 years (p<0.001), high blood pressure (p<0.01) and dyslipidemia (p<0.05). A multivariate analysis including these variables and biochemical vascular risk factors showed a predictor model including two variables: inducers group (p=0.031; Coefficient β=0.234) and age >50 years (p=0.001; Coefficient β=0.387). Regarding gender, the mean CIMT in males was significantly higher in the inducers (0.693mm; SD=0.139) than in the non- inducers groups (0.628mm; SD=0.151; p<0.05). In females the differences were not significant.
Significance: The use of CYP inducer AEDs is associated with a significant increase in CIMT as compared with ESL and other non-inducer AEDs. The study shows a decrease in the vascular risk measured by ultrasound criteria in male patients treated with ESL compared with patients treated with inducer AEDs.
(Copyright © 2017 Elsevier B.V. All rights reserved.)