학술논문
Case Report: Omicron BA.2 Subvariant of SARS-CoV-2 Outcompetes BA.1 in Two Co-infection Cases.
Document Type
Report
Author
Gjorgjievska M; Zan Mitrev Clinic, Skopje, North Macedonia.; Mehandziska S; Zan Mitrev Clinic, Skopje, North Macedonia.; Stajkovska A; Bio Engineering LLC, Skopje, North Macedonia.; Pecioska-Dokuzovska S; Zan Mitrev Clinic, Skopje, North Macedonia.; Dimovska A; Zan Mitrev Clinic, Skopje, North Macedonia.; Durmish I; Zan Mitrev Clinic, Skopje, North Macedonia.; Ismail S; Zan Mitrev Clinic, Skopje, North Macedonia.; Pavlovska T; Zan Mitrev Clinic, Skopje, North Macedonia.; Stojchevska A; Zan Mitrev Clinic, Skopje, North Macedonia.; Amedi H; Zan Mitrev Clinic, Skopje, North Macedonia.; Andonova J; Zan Mitrev Clinic, Skopje, North Macedonia.; Nikolovska M; Zan Mitrev Clinic, Skopje, North Macedonia.; Velickovikj S; Zan Mitrev Clinic, Skopje, North Macedonia.; Mitrev Z; Zan Mitrev Clinic, Skopje, North Macedonia.; Kungulovski I; Bio Engineering LLC, Skopje, North Macedonia.; Kungulovski G; Bio Engineering LLC, Skopje, North Macedonia.
Source
Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101560621 Publication Model: eCollection Cited Medium: Print ISSN: 1664-8021 (Print) Linking ISSN: 16648021 NLM ISO Abbreviation: Front Genet Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
1664-8021
Abstract
Trends from around the world suggest that the omicron BA.2 subvariant is increasing in proportion to the original BA.1 subvariant. Here we report two cases of co-infection with omicron BA.1 and omicron BA.2 in co-exposed individuals. In both individuals, genome sequencing and/or S-gene specific PCR identified omicron BA.1 at early time-points, which was replaced by omicron BA.2 at later time-points of the infection. The timeline of our data supports the proposition that BA.2 outcompetes BA.1 in a real-life scenario, and in time becomes the dominant variant in the upper respiratory tract of the host.
Competing Interests: AS, IK, and GK were employed by the company Bio Engineering LLC. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Gjorgjievska, Mehandziska, Stajkovska, Pecioska-Dokuzovska, Dimovska, Durmish, Ismail, Pavlovska, Stojchevska, Amedi, Andonova, Nikolovska, Velickovikj, Mitrev, Kungulovski and Kungulovski.)
Competing Interests: AS, IK, and GK were employed by the company Bio Engineering LLC. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Gjorgjievska, Mehandziska, Stajkovska, Pecioska-Dokuzovska, Dimovska, Durmish, Ismail, Pavlovska, Stojchevska, Amedi, Andonova, Nikolovska, Velickovikj, Mitrev, Kungulovski and Kungulovski.)