학술논문
Role of dopamine neurons in familiarity.
Document Type
Academic Journal
Author
Fleury S; The Advanced Science Research Center, Graduate Center, City University of New York, New York, New York, USA.; Kolaric R; The Advanced Science Research Center, Graduate Center, City University of New York, New York, New York, USA.; Espera J; The Advanced Science Research Center, Graduate Center, City University of New York, New York, New York, USA.; Ha Q; The Advanced Science Research Center, Graduate Center, City University of New York, New York, New York, USA.; Tomaio J; The Advanced Science Research Center, Graduate Center, City University of New York, New York, New York, USA.; Gether U; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Sørensen AT; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Mingote S; The Advanced Science Research Center, Graduate Center, City University of New York, New York, New York, USA.
Source
Publisher: Wiley-Blackwell Country of Publication: France NLM ID: 8918110 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-9568 (Electronic) Linking ISSN: 0953816X NLM ISO Abbreviation: Eur J Neurosci Subsets: MEDLINE
Subject
Language
English
Abstract
Dopamine neurons signal the salience of environmental stimuli and influence learning, although it is less clear if these neurons also determine the salience of memories. Ventral tegmental area (VTA) dopamine neurons increase their firing in the presence of new objects and reduce it upon repeated, inconsequential exposures, marking the shift from novelty to familiarity. This study investigates how dopamine neuron activity during repeated familiar object exposure affects an animal's preference for new objects in a subsequent novel object recognition (NOR) test. We hypothesize that a single familiarization session will not sufficiently lower dopamine activity, such that the memory of a familiar object remains salient, leading to equal exploration of familiar and novel objects and weaker NOR discrimination. In contrast, multiple familiarization sessions likely suppress dopamine activity more effectively, reducing the salience of the familiar object and enhancing subsequent novelty discrimination. Our experiments in mice indicated that multiple familiarization sessions reduce VTA dopamine neuron activation, as measured by c-Fos expression, and enhance novelty discrimination compared with a single familiarization session. Dopamine neurons that show responsiveness to novelty were primarily located in the paranigral nucleus of the VTA and expressed vesicular glutamate transporter 2 transcripts, marking them as dopamine-glutamate neurons. Chemogenetic inhibition of dopamine neurons during a single session paralleled the effects of multiple sessions, improving NOR. These findings suggest that a critical role of dopamine neurons during the transition from novelty to familiarity is to modulate the salience of an object's memory.
(© 2024 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)
(© 2024 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)