학술논문
Domain-specific cognitive impairments, mood and quality of life 6 months after stroke.
Document Type
Academic Journal
Author
Milosevich E; Department of Experimental Psychology, University of Oxford, UK.; Kusec A; Department of Experimental Psychology, University of Oxford, UK.; Pendlebury ST; Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford, UK.; NIHR Oxford Biomedical Research Centre and Departments of General Medicine and Geratology, John Radcliffe Hospital, Oxford, UK.; Demeyere N; Department of Experimental Psychology, University of Oxford, UK.; Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford, UK.
Source
Publisher: Taylor & Francis Country of Publication: England NLM ID: 9207179 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-5165 (Electronic) Linking ISSN: 09638288 NLM ISO Abbreviation: Disabil Rehabil Subsets: MEDLINE
Subject
Language
English
Abstract
Purpose: To identify which acute and 6-month domain-specific cognitive impairments impact mood, participation, and stroke-related quality of life 6 months post-stroke.
Materials and Methods: A prospective cohort of 430 stroke survivors completed the Oxford Cognitive Screen (OCS) acutely and 6 months post-stroke. Participants completed the Stroke Impact Scale (SIS) and Hospital Depression and Anxiety Scale (HADS) at 6 months. Multivariable regression analyses assessed whether severity of, and domain-specific, cognitive impairment acutely and at 6 months was associated with composite 6-month SIS scores, each SIS subscale, and HADS scores.
Results: Increased severity of acute and 6-month cognitive impairment was associated with lower 6-month SIS composite scores independent of age, sex, education years, and stroke severity (both p < 0.001). Domain-specific impairments in memory ( p < 0.001) and attention ( p = 0.002) acutely, and language ( p < 0.001), memory ( p = 0.001) and number processing ( p = 0.006) at 6 months showed the strongest associations with worse SIS composite scores. Severity of acute and 6-month cognitive impairment was associated with poorer functioning in each SIS subscale, and greater levels of depression (acute p = 0.021, 6-months p < 0.001), but not anxiety ( p = 0.174, p = 0.129).
Conclusions: Both acute and 6-month domain-specific cognitive impairments, particularly in memory, were found to negatively impact overall functional and mood outcomes 6 months post-stroke.
Materials and Methods: A prospective cohort of 430 stroke survivors completed the Oxford Cognitive Screen (OCS) acutely and 6 months post-stroke. Participants completed the Stroke Impact Scale (SIS) and Hospital Depression and Anxiety Scale (HADS) at 6 months. Multivariable regression analyses assessed whether severity of, and domain-specific, cognitive impairment acutely and at 6 months was associated with composite 6-month SIS scores, each SIS subscale, and HADS scores.
Results: Increased severity of acute and 6-month cognitive impairment was associated with lower 6-month SIS composite scores independent of age, sex, education years, and stroke severity (both p < 0.001). Domain-specific impairments in memory ( p < 0.001) and attention ( p = 0.002) acutely, and language ( p < 0.001), memory ( p = 0.001) and number processing ( p = 0.006) at 6 months showed the strongest associations with worse SIS composite scores. Severity of acute and 6-month cognitive impairment was associated with poorer functioning in each SIS subscale, and greater levels of depression (acute p = 0.021, 6-months p < 0.001), but not anxiety ( p = 0.174, p = 0.129).
Conclusions: Both acute and 6-month domain-specific cognitive impairments, particularly in memory, were found to negatively impact overall functional and mood outcomes 6 months post-stroke.