학술논문
Mechanism of surfactant interactions with feline coronavirus: A physical chemistry perspective.
Document Type
Academic Journal
Author
Mateos H; Department of Chemistry and CSGI (Centre for Colloid and Surface Science), University of Bari 'A. Moro', via Orabona 4, 70125 Bari, Italy. Electronic address: Helena.mateos@uniba.it.; Mallardi A; Institute for Physical and Chemical Processes, Bari Division, National Council of Research (CNR), c/o Chemistry Department, Via Orabona 4, 70125 Bari, Italy. Electronic address: antonia.mallardi@cnr.it.; Camero M; Department of Veterinary Medicine, University of Bari 'A. Moro', Strada Provinciale per Casamassima km. 3, 70010 Valenzano, Bari, Italy. Electronic address: michele.camero@uniba.it.; Lanave G; Department of Veterinary Medicine, University of Bari 'A. Moro', Strada Provinciale per Casamassima km. 3, 70010 Valenzano, Bari, Italy. Electronic address: gianvito.lanave@uniba.it.; Catella C; Department of Veterinary Medicine, University of Bari 'A. Moro', Strada Provinciale per Casamassima km. 3, 70010 Valenzano, Bari, Italy. Electronic address: cristiana.catella@uniba.it.; Buonavoglia A; Dental School, Department of Biomedical and Neuromotor Sciences, University of Bologna Alma Mater, Italy. Electronic address: alessio.buonavoglia85@gmail.com.; De Giglio O; Interdisciplinary Department of Medicine, Hygiene Section, University of Bari 'A. Moro', Piazza G. Cesare 11, 70124 Bari, Italy. Electronic address: osvalda.degiglio@uniba.it.; Buonavoglia C; Department of Veterinary Medicine, University of Bari 'A. Moro', Strada Provinciale per Casamassima km. 3, 70010 Valenzano, Bari, Italy. Electronic address: alessio.buonavoglia2@unibo.it.; Palazzo G; Department of Chemistry and CSGI (Centre for Colloid and Surface Science), University of Bari 'A. Moro', via Orabona 4, 70125 Bari, Italy. Electronic address: Gerardo.palazzo@uniba.it.
Source
Publisher: Academic Press Country of Publication: United States NLM ID: 0043125 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-7103 (Electronic) Linking ISSN: 00219797 NLM ISO Abbreviation: J Colloid Interface Sci Subsets: MEDLINE
Subject
Language
English
Abstract
Hypothesis: Surfactants are inexpensive chemicals with promising applications in virus inactivation, particularly for enveloped viruses. Yet, the detailed mechanisms by which surfactants deactivate coronaviruses remain underexplored. This study delves into the virucidal mechanisms of various surfactants on Feline Coronavirus (FCoV) and their potential applications against more pathogenic coronaviruses.
Experiments: By integrating virucidal activity assays with fluorescence spectroscopy, dynamic light scattering and laser Doppler electrophoresis, alongside liposome permeability experiments, we have analyzed the effects of non-ionic and ionic surfactants on viral activity.
Findings: The non-ionic surfactant octaethylene glycol monodecyl ether (C10 EO 8 ) inactivates the virus by disrupting the lipid envelope, whereas ionic surfactants like Sodium Dodecyl Sulfate and Cetylpyridinium Chloride predominantly affect the spike proteins, with their impact on the viral membrane being hampered by kinetic and thermodynamic constraints. FCoV served as a safe model for studying virucidal activity, offering a faster alternative to traditional virucidal assays. The study demonstrates that physicochemical techniques can expedite the screening of virucidal compounds, contributing to the design of effective disinfectant formulations. Our results not only highlight the critical role of surfactant-virus interactions but also contribute to strategic advancements in public health measures for future pandemic containment and the ongoing challenge of antimicrobial resistance.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
Experiments: By integrating virucidal activity assays with fluorescence spectroscopy, dynamic light scattering and laser Doppler electrophoresis, alongside liposome permeability experiments, we have analyzed the effects of non-ionic and ionic surfactants on viral activity.
Findings: The non-ionic surfactant octaethylene glycol monodecyl ether (C
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)