학술논문
Long Non-Coding RNAs: New Insights in Neurodegenerative Diseases.
Document Type
Academic Journal
Author
Anilkumar AK; Medicine and Oncology, ISU, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.; Vij P; Department of Pharmaceutical Sciences, St. John's University, Queens, NY 11439, USA.; Lopez S; Medicine and Oncology, ISU, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.; Leslie SM; Medicine and Oncology, ISU, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.; Doxtater K; Medicine and Oncology, ISU, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.; Khan MM; Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.; Yallapu MM; Medicine and Oncology, ISU, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.; Chauhan SC; Medicine and Oncology, ISU, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.; Maestre GE; Department of Neurosciences, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78550, USA.; South Texas Alzheimer's Disease Research Center, School of Medicine, University of Texas Rio Grande Valley, Harlingen, TX 78550, USA.; Tripathi MK; Medicine and Oncology, ISU, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
Source
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
Subject
Language
English
Abstract
Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS), are gradually becoming a burden to society. The adverse effects and mortality/morbidity rates associated with these NDDs are a cause of many healthcare concerns. The pathologic alterations of NDDs are related to mitochondrial dysfunction, oxidative stress, and inflammation, which further stimulate the progression of NDDs. Recently, long non-coding RNAs (lncRNAs) have attracted ample attention as critical mediators in the pathology of NDDs. However, there is a significant gap in understanding the biological function, molecular mechanisms, and potential importance of lncRNAs in NDDs. This review documents the current research on lncRNAs and their implications in NDDs. We further summarize the potential implication of lncRNAs to serve as novel therapeutic targets and biomarkers for patients with NDDs.