학술논문
The Relevance of Arterial Blood Pressure in the Management of Glaucoma Progression: A Systematic Review.
Document Type
Academic Journal
Author
Van Eijgen J; Department of Ophthalmology, University Hospitals UZ Leuven, Leuven, Belgium.; Research Group Ophthalmology, Department of Neurosciences, KU Leuven, Leuven, Belgium.; Melgarejo JD; Institute of Neurosciences, School of Medicine, University of Texas Rio Grande Valley, Harlingen, Texas, USA.; Rio Grande Valley Alzheimer's Disease Resource Center for Minority Aging Research (RGV AD-RCMAR), University of Texas Rio Grande Valley, Brownsville, Texas, USA.; Van Laeken J; Department of Ophthalmology, University Hospitals UZ Leuven, Leuven, Belgium.; Van der Pluijm C; Research Group Ophthalmology, Department of Neurosciences, KU Leuven, Leuven, Belgium.; Matheussen H; Research Group Ophthalmology, Department of Neurosciences, KU Leuven, Leuven, Belgium.; Verhaegen M; Department of Ophthalmology, University Hospitals UZ Leuven, Leuven, Belgium.; Research Group Ophthalmology, Department of Neurosciences, KU Leuven, Leuven, Belgium.; Van Keer K; Research Group Ophthalmology, Department of Neurosciences, KU Leuven, Leuven, Belgium.; Maestre GE; Institute of Neurosciences, School of Medicine, University of Texas Rio Grande Valley, Harlingen, Texas, USA.; Rio Grande Valley Alzheimer's Disease Resource Center for Minority Aging Research (RGV AD-RCMAR), University of Texas Rio Grande Valley, Brownsville, Texas, USA.; Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, Texas, USA.; Al-Aswad LA; Department of Ophthalmology, New York University (NYU) School of Medicine, NYU Langone Health, New York, USA.; Vanassche T; Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.; Zhang ZY; Research Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Sciences, KU Leuven , Leuven, Belgium.; Stalmans I; Department of Ophthalmology, University Hospitals UZ Leuven, Leuven, Belgium.; Research Group Ophthalmology, Department of Neurosciences, KU Leuven, Leuven, Belgium.
Source
Publisher: Oxford University Press Country of Publication: United States NLM ID: 8803676 Publication Model: Print Cited Medium: Internet ISSN: 1941-7225 (Electronic) Linking ISSN: 08957061 NLM ISO Abbreviation: Am J Hypertens Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Glaucoma is one of the leading causes of global blindness and is expected to co-occur more frequently with vascular morbidities in the upcoming years, as both are aging-related diseases. Yet, the pathogenesis of glaucoma is not entirely elucidated and the interplay between intraocular pressure, arterial blood pressure (BP) and ocular perfusion pressure is poorly understood.
Objectives: This systematic review aims to provide clinicians with the latest literature regarding the management of arterial BP in glaucoma patients.
Methods: A systematic search was performed in Medline, Embase, Web of Science and Cochrane Library. Articles written in English assessing the influence of arterial BP and systemic antihypertensive treatment of glaucoma and its management were eligible for inclusion. Additional studies were identified by revising references included in selected articles.
Results: 80 Articles were included in this systemic review. A bimodal relation between BP and glaucoma progression was found. Both high and low BP increase the risk of glaucoma. Glaucoma progression was, possibly via ocular perfusion pressure variation, strongly associated with nocturnal dipping and high variability in the BP over 24 h.
Conclusions: We concluded that systemic BP level associates with glaucomatous damage and provided recommendations for the management and study of arterial BP in glaucoma. Prospective clinical trials are needed to further support these recommendations.
(© The Author(s) 2023. Published by Oxford University Press on behalf of American Journal of Hypertension, Ltd.)
Objectives: This systematic review aims to provide clinicians with the latest literature regarding the management of arterial BP in glaucoma patients.
Methods: A systematic search was performed in Medline, Embase, Web of Science and Cochrane Library. Articles written in English assessing the influence of arterial BP and systemic antihypertensive treatment of glaucoma and its management were eligible for inclusion. Additional studies were identified by revising references included in selected articles.
Results: 80 Articles were included in this systemic review. A bimodal relation between BP and glaucoma progression was found. Both high and low BP increase the risk of glaucoma. Glaucoma progression was, possibly via ocular perfusion pressure variation, strongly associated with nocturnal dipping and high variability in the BP over 24 h.
Conclusions: We concluded that systemic BP level associates with glaucomatous damage and provided recommendations for the management and study of arterial BP in glaucoma. Prospective clinical trials are needed to further support these recommendations.
(© The Author(s) 2023. Published by Oxford University Press on behalf of American Journal of Hypertension, Ltd.)