학술논문
Opposing impacts of HLA-G haplotypes PROMO-G010104-UTR-3 and PROMO-G010101b/c-UTR-4 on risk of recurrent implantation failure.
Document Type
Academic Journal
Author
Papúchová H; Department of Clinical Biochemistry, Centre for Immune Regulation and Reproductive Immunology (CIRRI), Zealand University Hospital, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark; The ReproHealth Research Consortium, Zealand University Hospital, Denmark.; Saxtorph MH; Department of Clinical Medicine, University of Copenhagen, Denmark; The ReproHealth Research Consortium, Zealand University Hospital, Denmark; Department of Gynecology, Obstetrics and Fertility, Zealand University Hospital, Denmark.; Hallager T; The ReproHealth Research Consortium, Zealand University Hospital, Denmark; Department of Pathology, Zealand University Hospital, Denmark.; Jepsen IE; Department of Clinical Medicine, University of Copenhagen, Denmark; The ReproHealth Research Consortium, Zealand University Hospital, Denmark; Department of Gynecology, Obstetrics and Fertility, Zealand University Hospital, Denmark.; Eriksen JO; The ReproHealth Research Consortium, Zealand University Hospital, Denmark; Department of Pathology, Zealand University Hospital, Denmark.; Persson G; Department of Clinical Biochemistry, Centre for Immune Regulation and Reproductive Immunology (CIRRI), Zealand University Hospital, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark; The ReproHealth Research Consortium, Zealand University Hospital, Denmark.; Funck T; Department of Clinical Biochemistry, Centre for Immune Regulation and Reproductive Immunology (CIRRI), Zealand University Hospital, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark; The ReproHealth Research Consortium, Zealand University Hospital, Denmark.; Weisdorf I; Department of Clinical Biochemistry, Centre for Immune Regulation and Reproductive Immunology (CIRRI), Zealand University Hospital, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark; The ReproHealth Research Consortium, Zealand University Hospital, Denmark.; Macklon N; Department of Clinical Medicine, University of Copenhagen, Denmark; The ReproHealth Research Consortium, Zealand University Hospital, Denmark; Department of Gynecology, Obstetrics and Fertility, Zealand University Hospital, Denmark; London Women's Clinic, London, UK.; Larsen LG; The ReproHealth Research Consortium, Zealand University Hospital, Denmark; Department of Pathology, Zealand University Hospital, Denmark.; Hviid TVF; Department of Clinical Biochemistry, Centre for Immune Regulation and Reproductive Immunology (CIRRI), Zealand University Hospital, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark; The ReproHealth Research Consortium, Zealand University Hospital, Denmark. Electronic address: tvh@regionsjaelland.dk.
Source
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101122473 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1472-6491 (Electronic) Linking ISSN: 14726483 NLM ISO Abbreviation: Reprod Biomed Online Subsets: MEDLINE
Subject
Language
English
Abstract
Research Question: The human leukocyte antigen (HLA) class Ib molecules HLA-F and HLA-G are implicated in pregnancy success, but how do HLA-G and HLA-F genetic polymorphisms impact recurrent implantation failure (RIF)?
Design: Prospective cohort study at a fertility clinic including a cohort of 84 women experiencing RIF and 35 IVF controls to assess the influence of HLA-G haplotypes and diplotypes and HLA-F single nucleotide polymorphisms (SNP) on RIF.
Results: Over-representation trends for HLA-F SNP genotypes rs1362126, rs2523405 and rs2523393, previously linked with a short time-to-pregnancy, were detected in female control groups compared with RIF patients with no identified pathology linked to infertility. The HLA-G promoter haplotype PROMO-G010101b/c linked with the HLA-G 3'-untranslated region (3'UTR) haplotype UTR-4, which previously has been associated with positive IVF outcome and pregnancy success, was less frequent in the RIF group. For RIF patients carrying the UTR-4 haplotype, the odds ratio (OR) was 0.27 (95% CI 0.12-0.66; P = 0.0044, Pc = 0.026). The HLA-G PROMO-G010104-UTR-3 haplotype was associated with an increased risk of RIF. For RIF patients carrying the UTR-3 haplotype, the OR was 5.86 (95% CI 1.52-26.23; P = 0.0115, P c = 0.069).
Conclusions: These results show that specific HLA-G haplotypes based on the promoter region and the 3'UTR are either associated with an increased risk of reduced fertility, including the manifestation of RIF, and lower chance of achieving pregnancy, or with a reduced risk of experiencing RIF.
(Copyright © 2023 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.)
Design: Prospective cohort study at a fertility clinic including a cohort of 84 women experiencing RIF and 35 IVF controls to assess the influence of HLA-G haplotypes and diplotypes and HLA-F single nucleotide polymorphisms (SNP) on RIF.
Results: Over-representation trends for HLA-F SNP genotypes rs1362126, rs2523405 and rs2523393, previously linked with a short time-to-pregnancy, were detected in female control groups compared with RIF patients with no identified pathology linked to infertility. The HLA-G promoter haplotype PROMO-G010101b/c linked with the HLA-G 3'-untranslated region (3'UTR) haplotype UTR-4, which previously has been associated with positive IVF outcome and pregnancy success, was less frequent in the RIF group. For RIF patients carrying the UTR-4 haplotype, the odds ratio (OR) was 0.27 (95% CI 0.12-0.66; P = 0.0044, P
Conclusions: These results show that specific HLA-G haplotypes based on the promoter region and the 3'UTR are either associated with an increased risk of reduced fertility, including the manifestation of RIF, and lower chance of achieving pregnancy, or with a reduced risk of experiencing RIF.
(Copyright © 2023 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.)