학술논문
Can Repetitive Transcranial Magnetic Stimulation (rTMS) Promote Neurogenesis and Axonogenesis in Subacute Human Ischemic Stroke?
Document Type
Academic Journal
Author
De Michele M; Emergency Department, Stroke Unit, Policlinico Umberto I Hospital, Sapienza University, 00161 Rome, Italy.; Piscopo P; Department of Neuroscience, Italian National Institute of Health, 00161 Rome, Italy.; Costanzo M; Department of Neuroscience, Italian National Institute of Health, 00161 Rome, Italy.; Department of Human Neurosciences, Sapienza University, 00185 Rome, Italy.; Lorenzano S; Department of Human Neurosciences, Sapienza University, 00185 Rome, Italy.; Crestini A; Department of Neuroscience, Italian National Institute of Health, 00161 Rome, Italy.; Rivabene R; Department of Neuroscience, Italian National Institute of Health, 00161 Rome, Italy.; Manzini V; Department of Neuroscience, Italian National Institute of Health, 00161 Rome, Italy.; Department of Biology and Biotechnology Charles Darwin, Sapienza University, 00185 Rome, Italy.; Petraglia L; Emergency Department, Stroke Unit, Policlinico Umberto I Hospital, Sapienza University, 00161 Rome, Italy.; Iacobucci M; Neuroradiology Unit, Department of Human Neurosciences, Policlinico Umberto I Hospital, Sapienza University, 00161 Rome, Italy.; Berto I; Department of Human Neurosciences, Sapienza University, 00185 Rome, Italy.; Schiavo OG; Emergency Department, Stroke Unit, Policlinico Umberto I Hospital, Sapienza University, 00161 Rome, Italy.; Conte A; Department of Human Neurosciences, Sapienza University, 00185 Rome, Italy.; IRCCS Neuromed, 86077 Pozzilli, Italy.; Belvisi D; Department of Human Neurosciences, Sapienza University, 00185 Rome, Italy.; IRCCS Neuromed, 86077 Pozzilli, Italy.; Berardelli A; Department of Human Neurosciences, Sapienza University, 00185 Rome, Italy.; IRCCS Neuromed, 86077 Pozzilli, Italy.; Toni D; Department of Human Neurosciences, Sapienza University, 00185 Rome, Italy.
Source
Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
2227-9059
Abstract
Background: Ischemic stroke may trigger neuroplastic changes via proliferation, migration towards the lesion, and differentiation of neuroprogenitor cells into mature neurons. Repetitive Transcranial Magnetic Stimulation (rTMS) may promote brain plasticity. This study aimed to assess rTMS's effect on post-stroke endogenous neuroplasticity by dosing plasma miRs 17~92, Netrin-1, Sema3A, and BDNF.
Methods: In this case-controlled study, we randomized 19 ischemic stroke patients within five days from symptoms onset (T0) to neuronavigated-rTMS or sham stimulation. Stimulation was applied on the stroke hemisphere daily between the 7th and 14th day from stroke onset. Blood samples were collected at T0, before the first rTMS section (T7), and at the end of the last rTMS session (T14). Five healthy controls were also enrolled in this study.
Results: Of 19 patients, 10 received rTMS and 9 sham stimulation. Compared with the sham group, in the rTMS group, plasma levels of miRs17~92 and Ntn-1 significantly increased whereas Sema3A levels tended to decrease. In multivariate linear regression analyses, rTMS was independently related to Ntn-1 and miR-25 levels at T14.
Conclusions: We found an association between rTMS and neurogenesis/axonogenesis biomarker enhancement. Our preliminary data suggest that rTMS may positively interfere with natural endogenous plasticity phenomena of the post-ischemic human brain.
Methods: In this case-controlled study, we randomized 19 ischemic stroke patients within five days from symptoms onset (T0) to neuronavigated-rTMS or sham stimulation. Stimulation was applied on the stroke hemisphere daily between the 7th and 14th day from stroke onset. Blood samples were collected at T0, before the first rTMS section (T7), and at the end of the last rTMS session (T14). Five healthy controls were also enrolled in this study.
Results: Of 19 patients, 10 received rTMS and 9 sham stimulation. Compared with the sham group, in the rTMS group, plasma levels of miRs17~92 and Ntn-1 significantly increased whereas Sema3A levels tended to decrease. In multivariate linear regression analyses, rTMS was independently related to Ntn-1 and miR-25 levels at T14.
Conclusions: We found an association between rTMS and neurogenesis/axonogenesis biomarker enhancement. Our preliminary data suggest that rTMS may positively interfere with natural endogenous plasticity phenomena of the post-ischemic human brain.