학술논문
Simultaneous melanomas in the setting of multiple primary melanomas.
Document Type
Academic Journal
Author
Kostaki M; Department of Plastic Surgery, Microsurgery, Burns and Melanoma Reference Center, General Hospital of Athens G.Gennimatas.; Plaka M; First Department of Dermatology-Venereology, Medical School of Athens University, Andreas Syggros Hospital, Athens, Greece.; Befon A; First Department of Dermatology-Venereology, Medical School of Athens University, Andreas Syggros Hospital, Athens, Greece.; Dessinioti C; First Department of Dermatology-Venereology, Medical School of Athens University, Andreas Syggros Hospital, Athens, Greece.; Kypraiou K; First Department of Dermatology-Venereology, Medical School of Athens University, Andreas Syggros Hospital, Athens, Greece.; Chardalia V; First Department of Dermatology-Venereology, Medical School of Athens University, Andreas Syggros Hospital, Athens, Greece.; Christofidou E; First Department of Dermatology-Venereology, Medical School of Athens University, Andreas Syggros Hospital, Athens, Greece.; Polydorou D; First Department of Dermatology-Venereology, Medical School of Athens University, Andreas Syggros Hospital, Athens, Greece.; Stratigos A; First Department of Dermatology-Venereology, Medical School of Athens University, Andreas Syggros Hospital, Athens, Greece.
Source
Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 9109623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5636 (Electronic) Linking ISSN: 09608931 NLM ISO Abbreviation: Melanoma Res Subsets: MEDLINE
Subject
Language
English
Abstract
It is estimated that about 1-13% of melanoma patients will develop multiple primary melanomas. Although the occurrence of subsequent tumors has been described during the last few years, the development of simultaneous melanomas has not yet been extensively studied. We reviewed our registries to identify patients with multiple primary melanomas. We studied epidemiological, clinical, and histological characteristics of patients who were diagnosed with simultaneous melanomas and compared them with those of patients who developed non-synchronous multiple primary melanomas. As simultaneous were defined subsequent melanomas that were diagnosed either at the same visit or within a time-period of maximum of 1 month. Between 2000 and 2020, 2500 patients were diagnosed with melanoma at Andreas Syggros Hospital. 86 (3.4%) patients presented multiple primary melanomas and among them, 35 (40.7%) developed simultaneous melanomas. Patients with simultaneous melanomas developed more frequently more than 2 tumors. First tumors of patients with non-synchronous melanomas were significantly thicker than second tumors while those of patients with simultaneous melanomas did not differ significantly. Slight differences in the tumor localization, staging and histologic type were observed between the two groups. However significant differences were ascertained between first and second tumors in both groups. Simultaneous melanomas occupy an important proportion of multiple primary melanomas, affecting a non-negligible number of patients. Slight differences between simultaneous and non-synchronous multiple primary melanomas seem to define a distinct subcategory of multiple primary melanomas.
(Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
(Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)