학술논문
Sleep and circadian differences between light and heavy adult alcohol drinkers.
Document Type
Academic Journal
Author
Burgess HJ; Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.; Rizvydeen M; Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.; Kikyo F; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.; Kebbeh N; Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.; Tan M; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.; Roecklein KA; Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Hasler BP; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; King AC; Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA.; Cao D; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.
Source
Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7707242 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0277 (Electronic) Linking ISSN: 01456008 NLM ISO Abbreviation: Alcohol Clin Exp Res Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Numerous studies have reported that eveningness is associated with increased alcohol consumption. However, biological markers of circadian timing, such as dim light melatonin onset (DLMO) and circadian photoreceptor responsivity (post-illumination pupil response, PIPR), have rarely been assessed in the context of habitual alcohol consumption. This study aimed to examine sleep, circadian timing, and photoreceptor responsivity in adult alcohol drinkers.
Methods: Participants (21 to 45 years) included 28 light and 50 heavy drinkers. The 8-day study consisted of a week of ad lib sleep monitored with wrist actigraphy, followed by a 9-h laboratory session with a photoreceptor responsivity and circadian phase assessment.
Results: The heavy drinkers obtained on average 28 more minutes of sleep (p = 0.002) and reported more eveningness than the light drinkers (p = 0.029). There was a trend for a shorter DLMO-midsleep interval (p = 0.059) in the heavy drinkers, reflecting a tendency for them to sleep at an earlier circadian phase. The PIPR in the heavy drinkers was significantly smaller than in the light drinkers (p = 0.032), suggesting reduced circadian photoreceptor responsivity in the heavy drinkers. A larger PIPR was significantly associated with a later DLMO in the light drinkers (r = 0.44, p = 0.019), but this relationship was absent in the heavy drinkers (r = -0.01, p = 0.94).
Conclusions: These results are consistent with earlier reports of more eveningness and a shorter DLMO-midsleep interval being associated with heavier alcohol drinking. The novel finding of reduced circadian photoreceptor responsivity in heavy drinkers is consistent with prior rodent studies. Future studies should explore the impact of habitual alcohol consumption on other measures of circadian photoreceptor responsivity.
(© 2022 The Authors. Alcoholism: Clinical & Experimental Research published by Wiley Periodicals LLC on behalf of Research Society on Alcoholism.)
Methods: Participants (21 to 45 years) included 28 light and 50 heavy drinkers. The 8-day study consisted of a week of ad lib sleep monitored with wrist actigraphy, followed by a 9-h laboratory session with a photoreceptor responsivity and circadian phase assessment.
Results: The heavy drinkers obtained on average 28 more minutes of sleep (p = 0.002) and reported more eveningness than the light drinkers (p = 0.029). There was a trend for a shorter DLMO-midsleep interval (p = 0.059) in the heavy drinkers, reflecting a tendency for them to sleep at an earlier circadian phase. The PIPR in the heavy drinkers was significantly smaller than in the light drinkers (p = 0.032), suggesting reduced circadian photoreceptor responsivity in the heavy drinkers. A larger PIPR was significantly associated with a later DLMO in the light drinkers (r = 0.44, p = 0.019), but this relationship was absent in the heavy drinkers (r = -0.01, p = 0.94).
Conclusions: These results are consistent with earlier reports of more eveningness and a shorter DLMO-midsleep interval being associated with heavier alcohol drinking. The novel finding of reduced circadian photoreceptor responsivity in heavy drinkers is consistent with prior rodent studies. Future studies should explore the impact of habitual alcohol consumption on other measures of circadian photoreceptor responsivity.
(© 2022 The Authors. Alcoholism: Clinical & Experimental Research published by Wiley Periodicals LLC on behalf of Research Society on Alcoholism.)