학술논문
Neonatal haemostatic parameters in correlation to gestational age and birth weight.
Document Type
Academic Journal
Author
Mitsiakos G; Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, 'Papageorgiou' Hospital, Thessaloniki, Greece.; Katsaras GN; Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, 'Papageorgiou' Hospital, Thessaloniki, Greece.; Pouliakis A; Second Department of Pathology, National and Kapodistrian University of Athens, 'ATTIKON' University Hospital, Athens, Greece.; Papadakis E; Hematology Department - Hemostasis Unit, 'Papageorgiou' Hospital, Thessaloniki, Greece.; Chatziioannidis I; Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, 'Papageorgiou' Hospital, Thessaloniki, Greece.; Mitsiakou C; Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, 'Papageorgiou' Hospital, Thessaloniki, Greece.; Gialamprinou D; Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, 'Papageorgiou' Hospital, Thessaloniki, Greece.; Papacharalampous E; Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, 'Papageorgiou' Hospital, Thessaloniki, Greece.; Kioumi A; Hematology Department - Hemostasis Unit, 'Papageorgiou' Hospital, Thessaloniki, Greece.; Athanasiou M; First Paediatric Department, Aristotle University of Thessaloniki, Thessaloniki, Greece.; Athanassiadou F; Second Paediatric Department, Aristotle University of Thessaloniki, Thessaloniki, Greece.; Sfoungaris D; First Department of Pediatric Surgery, Faculty of Medicine, Aristotle University of Thessaloniki, 'G. Genimatas' Hospital, Thessaloniki, Greece.; Nikolaidis N; Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, 'Papageorgiou' Hospital, Thessaloniki, Greece.
Source
Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 101300213 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1751-553X (Electronic) Linking ISSN: 17515521 NLM ISO Abbreviation: Int J Lab Hematol Subsets: MEDLINE
Subject
Language
English
Abstract
Introduction: The aim of our study was to establish reference ranges for neonatal coagulation and fibrinolysis parameters and to investigate their relationship with gestational age (GA) and birth weight (BW).
Methods: A single-centre prospective study was conducted in all healthy neonates born in our hospital during the study period, excluding those with maternal or neonatal disorders and diseases that affect haemostasis. The following parameters were measured: fibrinogen, prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT) as well as factors II, V, VII, VIII, IX, X, XI and XII, von Willebrand (vWF), protein C, free protein S, antithrombin (AT), activated protein C resistance (APCr), tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1).
Results: Study population consisted of 327 neonates. Fibrinogen, AT III, proteins C and S, PAI-1, vWF and factors II, V, VIII, IX, XI and XII were positively correlated, while PT, aPPT, INR, APCr and tPA were negatively correlated with GA and BW. Proteins C and S, factors II, VIII, IX, XI and vWF, as well AT III and PAI-1 had a significant positive linear correlation with GA, while aPTT had a significant negative one. Fibrinogen, and factors V, VII and XII had a significant positive linear correlation with BW, while factor VIII, tPA, as well PT and INR had a significant negative one.
Conclusion: Fibrinogen, AT III, proteins C and S, PAI-1, vWF and factors II, V, VIII, IX, XI and XII increase with GA and BW.
(© 2022 John Wiley & Sons Ltd.)
Methods: A single-centre prospective study was conducted in all healthy neonates born in our hospital during the study period, excluding those with maternal or neonatal disorders and diseases that affect haemostasis. The following parameters were measured: fibrinogen, prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT) as well as factors II, V, VII, VIII, IX, X, XI and XII, von Willebrand (vWF), protein C, free protein S, antithrombin (AT), activated protein C resistance (APCr), tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1).
Results: Study population consisted of 327 neonates. Fibrinogen, AT III, proteins C and S, PAI-1, vWF and factors II, V, VIII, IX, XI and XII were positively correlated, while PT, aPPT, INR, APCr and tPA were negatively correlated with GA and BW. Proteins C and S, factors II, VIII, IX, XI and vWF, as well AT III and PAI-1 had a significant positive linear correlation with GA, while aPTT had a significant negative one. Fibrinogen, and factors V, VII and XII had a significant positive linear correlation with BW, while factor VIII, tPA, as well PT and INR had a significant negative one.
Conclusion: Fibrinogen, AT III, proteins C and S, PAI-1, vWF and factors II, V, VIII, IX, XI and XII increase with GA and BW.
(© 2022 John Wiley & Sons Ltd.)