학술논문
Acute effect of transcranial direct current stimulation on photoparoxysmal response.
Document Type
Academic Journal
Author
Yılmaz Erol T; Departments of Neurology and Clinical Neurophysiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. Electronic address: drtulayilmaz@gmail.com.; İlgezdi Kaya İ; Departments of Neurology and Clinical Neurophysiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. Electronic address: iremilgezdi@yahoo.com.; Ur Özçelik E; Department of Neurology, University of Health Sciences, Kanuni Sultan Süleyman Education and Research Hospital, Istanbul, Turkey. Electronic address: emeluscas@gmail.com.; Aksu S; Department of Physiology, Faculty of Medicine, Muğla Sıtkı Koçman University, Muğla, Turkey. Electronic address: serkanaksu@mu.edu.tr.; Şirin NG; Departments of Neurology and Clinical Neurophysiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. Electronic address: gorkemsirin@yahoo.com.tr.; Bebek N; Departments of Neurology and Clinical Neurophysiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. Electronic address: nersesb@yahoo.com.; Kurt A; Department of Physiology, School of Medicine, Koç University, Istanbul, Turkey. Electronic address: adnan.kurt@gmail.com.; Karamürsel S; Department of Physiology, School of Medicine, Koç University, Istanbul, Turkey. Electronic address: skaramursel@ku.edu.tr.; Baykan B; Departments of Neurology and Clinical Neurophysiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey; Department of Neurology, EMAR Medical Center, Istanbul, Turkey. Electronic address: baykanb@istanbul.edu.tr.
Source
Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8703089 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6844 (Electronic) Linking ISSN: 09201211 NLM ISO Abbreviation: Epilepsy Res Subsets: MEDLINE
Subject
Language
English
Abstract
Introduction: Transcranial direct current stimulation (tDCS) is a non-invasive technique, used to modify the excitability of the central nervous system. The main mechanism of tDCS is to change the excitability by subthreshold modulation by affecting neuronal membrane potentials in the direction of depolarization or repolarization. tDCS was previously investigated as an alternative adjunctive therapy in patients with epilepsy. We aimed here to investigate the acute effect of tDCS on the photoparoxysmal response (PPR) in EEG.
Methods: We enrolled 11 consecutive patients diagnosed with idiopathic generalized epilepsy who had PPR on at least 2 EEGs. Three different procedures, including sham, anodal, and cathodal tDCS were applied to the patients at intervals of one week by placing the active electrode over Oz, for 2 mA, 20 minutes. Spike-wave indices (SWI) were counted by two researchers independently and were compared during intermittent photic stimulation (IPS) on EEGs both before and after the application.
Results: After cathodal tDCS, SWI increased compared to baseline EEG and sham EEG in 3 patients, and after anodal tDCS, SWI increased in 2 patients. Although the SWI values did not change significantly, 8 patients reported subjectively that the applications were beneficial for them and that they experienced less discomfort during photic stimulation after the sessions. There were no side effects except transient skin rash in one patient, only.
Conclusions: In our sham controlled tDCS study with both cathodal and anodal stimulation, our data showed that there was no significant change in SWI during IPS, despite subjective well-being. tDCS' modulatory effect does not seem to act in the acute phase on EEG parameters after photic stimulation.
Competing Interests: Declaration of Competing Interest None of the authors have any conflict of interest to disclose. Written informed consent was obtained from the patient.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Methods: We enrolled 11 consecutive patients diagnosed with idiopathic generalized epilepsy who had PPR on at least 2 EEGs. Three different procedures, including sham, anodal, and cathodal tDCS were applied to the patients at intervals of one week by placing the active electrode over Oz, for 2 mA, 20 minutes. Spike-wave indices (SWI) were counted by two researchers independently and were compared during intermittent photic stimulation (IPS) on EEGs both before and after the application.
Results: After cathodal tDCS, SWI increased compared to baseline EEG and sham EEG in 3 patients, and after anodal tDCS, SWI increased in 2 patients. Although the SWI values did not change significantly, 8 patients reported subjectively that the applications were beneficial for them and that they experienced less discomfort during photic stimulation after the sessions. There were no side effects except transient skin rash in one patient, only.
Conclusions: In our sham controlled tDCS study with both cathodal and anodal stimulation, our data showed that there was no significant change in SWI during IPS, despite subjective well-being. tDCS' modulatory effect does not seem to act in the acute phase on EEG parameters after photic stimulation.
Competing Interests: Declaration of Competing Interest None of the authors have any conflict of interest to disclose. Written informed consent was obtained from the patient.
(Copyright © 2024 Elsevier B.V. All rights reserved.)