학술논문
SARS-CoV-2 Seroprevalence in a Cohort of International Travellers Returning to Rural Australia: Enablers and Barriers to Containment of COVID-19.
Document Type
Academic Journal
Author
Jackson J; Faculty of Medicine, University of New South Wales (UNSW) Rural Clinical School, Albury Campus, Australia; Albury-Wodonga Health, Australia. Electronic address: justin.jackson@awh.org.au.; Chan C; Albury-Wodonga Health, Australia.; McBurnie J; Border Medical Oncology Research Unit, Albury-Wodonga Regional Cancer Centre, Albury, New South Wales, Australia.; La Hera-Fuentes G; Faculty of Medicine, University of New South Wales (UNSW) Rural Clinical School, Coffs Harbour Campus, Australia.; Burston J; Faculty of Medicine, University of New South Wales (UNSW) Rural Clinical School, Albury Campus, Australia; Albury-Wodonga Health, Australia.; Bridges L; Faculty of Medicine, University of New South Wales (UNSW) Rural Clinical School, Albury Campus, Australia.; Underhill C; Albury-Wodonga Health, Australia; Border Medical Oncology Research Unit, Albury-Wodonga Regional Cancer Centre, Albury, New South Wales, Australia.; Eek R; Albury-Wodonga Health, Australia; Border Medical Oncology Research Unit, Albury-Wodonga Regional Cancer Centre, Albury, New South Wales, Australia.; Hueston L; NSW Health Pathology - Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW, Australia.; O'Sullivan M; NSW Health Pathology - Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW, Australia.; Dwyer DE; NSW Health Pathology - Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW, Australia.
Source
Publisher: Elsevier Country of Publication: United States NLM ID: 9611095 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1753-6405 (Electronic) Linking ISSN: 13260200 NLM ISO Abbreviation: Aust N Z J Public Health Subsets: MEDLINE
Subject
Language
English
Abstract
Objective: To describe the effectiveness of the public health response to COVID-19 in our local region by documenting detection of SARS-CoV-2 infection by nucleic acid testing (NAT) positivity and seroprevalence.
Methods: In this prospective study (ACTRN12620000487910), symptomatic adult international travellers returning to regional Australia in March 2020 underwent SARS-CoV-2 NAT and SARS-CoV-2-specific serology.
Results: Ninety-nine eligible participants were included. Nine participants had laboratory confirmed SARS-CoV-2, all returning between 16-20 March 2020. Eight (89%) had a positive NAT and seven (78%) had a positive serology test. The majority returned from New Zealand. Participants most frequently presented with cough (100%), headache (66.7%) and sore throat (44.4%). No community cases were detected from 1 March to 30 June 2020.
Conclusions: The study cohort of international travellers returning to regional Australia in March 2020 returned eight positive SARS-CoV-2 NAT results over a five-day window. Serology identified one additional case and was negative in two cases who were PCR positive. Longitudinal data confirmed an absence of local community transmission to 30 June 2020.
Implications for Public Health: A combination of local, national and environmental factors were necessary to prevent the establishment of community transmission in our local region.
(Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.)
Methods: In this prospective study (ACTRN12620000487910), symptomatic adult international travellers returning to regional Australia in March 2020 underwent SARS-CoV-2 NAT and SARS-CoV-2-specific serology.
Results: Ninety-nine eligible participants were included. Nine participants had laboratory confirmed SARS-CoV-2, all returning between 16-20 March 2020. Eight (89%) had a positive NAT and seven (78%) had a positive serology test. The majority returned from New Zealand. Participants most frequently presented with cough (100%), headache (66.7%) and sore throat (44.4%). No community cases were detected from 1 March to 30 June 2020.
Conclusions: The study cohort of international travellers returning to regional Australia in March 2020 returned eight positive SARS-CoV-2 NAT results over a five-day window. Serology identified one additional case and was negative in two cases who were PCR positive. Longitudinal data confirmed an absence of local community transmission to 30 June 2020.
Implications for Public Health: A combination of local, national and environmental factors were necessary to prevent the establishment of community transmission in our local region.
(Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.)