학술논문
Intra-breath changes in respiratory mechanics are sensitive to history of respiratory illness in preschool children: the SEPAGES cohort.
Document Type
Academic Journal
Author
Siroux V; University Grenoble Alpes, Inserm U1209, CNRS UMR5309, Team of Environmental Epidemiology Applied to the Development and Respiratory Health, Institute for Advanced Biosciences, IAB, Grenoble, 38000, France. valerie.siroux@univ-grenoble-alpes.fr.; Boudier A; University Grenoble Alpes, Inserm U1209, CNRS UMR5309, Team of Environmental Epidemiology Applied to the Development and Respiratory Health, Institute for Advanced Biosciences, IAB, Grenoble, 38000, France.; CHU Grenoble-Alpes, Grenoble, France.; Lyon-Caen S; University Grenoble Alpes, Inserm U1209, CNRS UMR5309, Team of Environmental Epidemiology Applied to the Development and Respiratory Health, Institute for Advanced Biosciences, IAB, Grenoble, 38000, France.; Quentin J; University Grenoble Alpes, Inserm U1209, CNRS UMR5309, Team of Environmental Epidemiology Applied to the Development and Respiratory Health, Institute for Advanced Biosciences, IAB, Grenoble, 38000, France.; CHU Grenoble-Alpes, Grenoble, France.; Gioria Y; University Grenoble Alpes, Inserm U1209, CNRS UMR5309, Team of Environmental Epidemiology Applied to the Development and Respiratory Health, Institute for Advanced Biosciences, IAB, Grenoble, 38000, France.; CHU Grenoble-Alpes, Grenoble, France.; Hantos Z; Department of Anesthesiology and Intensive Therapy, Semmelweis University, Budapest, Hungary.; Department of Technical Informatics and Engineering, University of Szeged, Szeged, Hungary.; Slama R; University Grenoble Alpes, Inserm U1209, CNRS UMR5309, Team of Environmental Epidemiology Applied to the Development and Respiratory Health, Institute for Advanced Biosciences, IAB, Grenoble, 38000, France.; Pin I; University Grenoble Alpes, Inserm U1209, CNRS UMR5309, Team of Environmental Epidemiology Applied to the Development and Respiratory Health, Institute for Advanced Biosciences, IAB, Grenoble, 38000, France.; CHU Grenoble-Alpes, Grenoble, France.; Bayat S; University Grenoble Alpes, Dept. of Pulmonology, STROBE Inserm UA7 Laboratory, Grenoble, France.
Source
Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101090633 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-993X (Electronic) Linking ISSN: 14659921 NLM ISO Abbreviation: Respir Res Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Intra-breath oscillometry has been proposed as a sensitive means of detecting airway obstruction in young children. We aimed to assess the impact of early life wheezing and lower respiratory tract illness on lung function, using both standard and intra-breath oscillometry in 3 year old children.
Methods: History of doctor-diagnosed asthma, wheezing, bronchiolitis and bronchitis and hospitalisation for respiratory problems were assessed by questionnaires in 384 population-based children. Association of respiratory history with standard and intra-breath oscillometry parameters, including resistance at 7 Hz (R7 ), frequency-dependence of resistance (R 7 - 19 ), reactance at 7 Hz (X 7 ), area of the reactance curve (AX), end-inspiratory and end-expiratory R (R eI , R eE ) and X (X eI , X eE ), and volume-dependence of resistance (ΔR = R eE -R eI ) was estimated by linear regression adjusted on confounders.
Results: Among the 320 children who accepted the oscillometry test, 281 (88%) performed 3 technically acceptable and reproducible standard oscillometry measurements and 251 children also performed one intra-breath oscillometry measurement. Asthma was associated with higher ReI , R eE , ΔR and R 7 and wheezing was associated with higher ΔR. Bronchiolitis was associated with higher R 7 and AX and lower X eI and bronchitis with higher R eI . No statistically significant association was observed for hospitalisation.
Conclusions: Our findings confirm the good success rate of oscillometry in 3-year-old children and indicate an association between a history of early-life wheezing and lower respiratory tract illness and lower lung function as assessed by both standard and intra-breath oscillometry. Our study supports the relevance of using intra-breath oscillometry parameters as sensitive outcome measures in preschool children in epidemiological cohorts.
(© 2024. The Author(s).)
Methods: History of doctor-diagnosed asthma, wheezing, bronchiolitis and bronchitis and hospitalisation for respiratory problems were assessed by questionnaires in 384 population-based children. Association of respiratory history with standard and intra-breath oscillometry parameters, including resistance at 7 Hz (R
Results: Among the 320 children who accepted the oscillometry test, 281 (88%) performed 3 technically acceptable and reproducible standard oscillometry measurements and 251 children also performed one intra-breath oscillometry measurement. Asthma was associated with higher R
Conclusions: Our findings confirm the good success rate of oscillometry in 3-year-old children and indicate an association between a history of early-life wheezing and lower respiratory tract illness and lower lung function as assessed by both standard and intra-breath oscillometry. Our study supports the relevance of using intra-breath oscillometry parameters as sensitive outcome measures in preschool children in epidemiological cohorts.
(© 2024. The Author(s).)