학술논문
Low vitamin D status is associated with anaemia in hospitalised cats.
Document Type
Academic Journal
Author
Titmarsh HF; Hospital for Small Animals, Royal Dick School of Veterinary Studies and The Roslin Institute, Edinburgh, UK.; Woods GA; Hospital for Small Animals, University of Edinburgh, Edinburgh, UK.; Cartwright JA; Hospital for Small Animals, Royal Dick School of Veterinary Studies and The Roslin Institute, Edinburgh, UK.; Hospital for Small Animals, University of Edinburgh, Edinburgh, UK.; Kilpatrick S; Division of Veterinary Clinical Studies, University of Edinburgh, Edinburgh, UK.; Gaylor D; Division of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, Edinburgh, UK.; Berry J; Clinical Biochemistry, Manchester Royal Infirmary, Manchester, UK.; Gow A; Internal Medicine, University of Edinburgh, Edinburgh, UK.; Bommer NX; Division of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, Edinburgh, UK.; Gunn-Moore D; Easter Bush Veterinary Centre, Royal (Dick) School of Veterinary Studies, Edinburgh, UK.; Handel I; Centre for Infectious Diseases, University of Edinburgh, Edinburgh, UK.; Mellanby RJ; Division of Veterinary Clinical Studies, University of Edinburgh, Edinburgh, UK.
Source
Publisher: Wiley Country of Publication: England NLM ID: 0031164 Publication Model: Print Cited Medium: Internet ISSN: 2042-7670 (Electronic) Linking ISSN: 00424900 NLM ISO Abbreviation: Vet Rec Subsets: MEDLINE
Subject
Language
English
Abstract
Background: The major physiological role of vitamin D has traditionally been considered to be the regulation of calcium homeostasis and maintenance of skeletal health. However, there is increasing evidence that vitamin D influences a wider range of physiological processes including erythropoiesis. Vitamin D (25-hydroxyvitamin D, 25(OH)D) deficiency concentrations have been associated with anaemia in human beings. In contrast, the relationship between vitamin D status and erythropoiesis has not been investigated in cats.
Methods: Clinical records of cats consecutively presenting between November 2013 and February 2015 were reviewed. For each cat, data including sex, age, breed, serum albumin and creatinine concentrations, and appetite scores were extracted. A multivariable linear regression model was constructed to examine the relationship between 25(OH)D concentrations and these variables.
Results: Cats with anaemia had significantly lower 25(OH)D concentrations (median 49.5 nmol/l, n=31) than cats with packed cell volume above the lower limit of the reference range (median 109.0 nmol/l, n=130) (P<0.001). A binary logistic regression found that red blood cell count and mean corpuscular volume were negatively correlated with serum 25(OH)D concentrations (P<0.001 and P=0.007, respectively).
Conclusion: Vitamin D (25(OH)D) concentration is positively associated with red blood cell count and mean corpuscular volume in cats with a wide range of different illnesses.
(© British Veterinary Association 2020.)
Methods: Clinical records of cats consecutively presenting between November 2013 and February 2015 were reviewed. For each cat, data including sex, age, breed, serum albumin and creatinine concentrations, and appetite scores were extracted. A multivariable linear regression model was constructed to examine the relationship between 25(OH)D concentrations and these variables.
Results: Cats with anaemia had significantly lower 25(OH)D concentrations (median 49.5 nmol/l, n=31) than cats with packed cell volume above the lower limit of the reference range (median 109.0 nmol/l, n=130) (P<0.001). A binary logistic regression found that red blood cell count and mean corpuscular volume were negatively correlated with serum 25(OH)D concentrations (P<0.001 and P=0.007, respectively).
Conclusion: Vitamin D (25(OH)D) concentration is positively associated with red blood cell count and mean corpuscular volume in cats with a wide range of different illnesses.
(© British Veterinary Association 2020.)