학술논문
Neuroinflammation in Sepsis: Molecular Pathways of Microglia Activation.
Document Type
Academic Journal
Author
Moraes CA; Immunopharmacology Lab, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21045-900, Brazil.; Zaverucha-do-Valle C; National Institute of Infectious Disease Evandro Chagas, Oswaldo Cruz Foundation, Ministry of Health, Rio de Janeiro 21040-360, Brazil.; Fleurance R; UCB Biopharma SRL, 1420 Braine L'Alleud, Belgium.; Experimental Neuropathology, Infection, and Epidemiology Department, Institut Pasteur, 75015 Paris, France.; Université de Paris Sciences et Lettres, 75006 Paris Paris, France.; Sharshar T; Experimental Neuropathology, Infection, and Epidemiology Department, Institut Pasteur, 75015 Paris, France.; Neuro-Anesthesiology and Intensive Care Medicine, Sainte-Anne Hospital, Paris-Descartes University, 75015 Paris, France.; Bozza FA; National Institute of Infectious Disease Evandro Chagas, Oswaldo Cruz Foundation, Ministry of Health, Rio de Janeiro 21040-360, Brazil.; D'Or Institute for Research and Education, Rio de Janeiro 22281-100, Brazil.; d'Avila JC; Immunopharmacology Lab, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21045-900, Brazil.; School of Medicine, Universidade Iguaçu, Rio de Janeiro 26260-045, Brazil.
Source
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print) Linking ISSN: 14248247 NLM ISO Abbreviation: Pharmaceuticals (Basel) Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
1424-8247
Abstract
Frequently underestimated, encephalopathy or delirium are common neurological manifestations associated with sepsis. Brain dysfunction occurs in up to 80% of cases and is directly associated with increased mortality and long-term neurocognitive consequences. Although the central nervous system (CNS) has been classically viewed as an immune-privileged system, neuroinflammation is emerging as a central mechanism of brain dysfunction in sepsis. Microglial cells are major players in this setting. Here, we aimed to discuss the current knowledge on how the brain is affected by peripheral immune activation in sepsis and the role of microglia in these processes. This review focused on the molecular pathways of microglial activity in sepsis, its regulatory mechanisms, and their interaction with other CNS cells, especially with neuronal cells and circuits.