학술논문
A critical view on autoantibodies in lupus nephritis: Concrete knowledge based on evidence.
Document Type
Academic Journal
Author
Bruschi M; Laboratory of Molecular Nephrology, IRCCS Istituto Giannina Gaslini, Genoa, Italy.; Angeletti A; Division of Nephrology, Dialysis and Transplantation, IRCCS Istituto Giannina Gaslini, Genoa, Italy.; Prunotto M; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.; Meroni PL; Experimental Laboratory of Immunological and Rheumatologic Researches, Istituto Auxologico Italiano-Istituto di Ricovero e Cura a Carattere Scientifico, Milano, Italy. Electronic address: pierluigi.meroni@unimi.it.; Ghiggeri GM; Laboratory of Molecular Nephrology, IRCCS Istituto Giannina Gaslini, Genoa, Italy; Division of Nephrology, Dialysis and Transplantation, IRCCS Istituto Giannina Gaslini, Genoa, Italy. Electronic address: gmarcoghiggeri@gaslini.org.; Moroni G; Department of Biomedical Sciences, Humanitas University and IRCCS Humanitas Research Hospital, Milan, Italy.; Sinico RA; Department of Medicine and surgery, University of Milan, Bicocca, Italy.; Franceschini F; Rheumatology and Clinical Immunology, ASST SpedaliCivili and Università of Brescia, Italy.; Fredi M; Rheumatology and Clinical Immunology, ASST SpedaliCivili and Università of Brescia, Italy.; Vaglio A; Department of Biomedical, Experimental and Clinical Sciences 'Mario Serio', University of Firenze, and Nephrology and Dialysis Unit, Meyer Children's Hospital, Firenze, Italy.; Cavalli A; Institute for Research in Biomedicine, Università della Svizzera Italiana, Bellinzona, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Scapozza L; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.; Patel JJ; Nimble Therapeutics, Madison, WI, USA.; Tan JC; Nimble Therapeutics, Madison, WI, USA.; Lo KC; Nimble Therapeutics, Madison, WI, USA.; Cavagna L; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia, Italy.; Petretto A; Core Facilities-Proteomics Laboratory, IRCCS Istituto Giannina Gaslini, Genoa, Italy.; Pratesi F; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa, Italy.; Migliorini P; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa, Italy.; Locatelli F; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia, Italy.; Pazzola G; Nephrology and Dialysis, Arciospedale Santa Maria nuova, Reggio Emilia, Italy.; Pesce G; Nephrology and Dialysis, Arciospedale Santa Maria nuova, Reggio Emilia, Italy.; Giannese D; Nephrology Chair, University of Pisa, Italy.; Manfredi A; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milano, Italy.; Ramirez GA; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milano, Italy.; Esposito P; Division of Nephrology, University of Genoa and Policlinico San Martino, Genova, Italy.; Murdaca G; Department of Internal Medicine, University of Genoa, Italy.; Negrini S; Department of Internal Medicine, University of Genoa, Italy.; Bui F; Division of Nephrology, University of Genoa and Policlinico San Martino, Genova, Italy.; Trezzi B; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Emmi G; Lupus Clinic Department of biomedicine, University of Florence, University Hospital Careggi, Florence, Italy.; Cavazzana I; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.; Binda V; Department of Biomedical, Experimental and Clinical Sciences 'Mario Serio', University of Firenze, and Nephrology and Dialysis Unit, Meyer Children's Hospital, Firenze, Italy.; Fenaroli P; Nephrology Unit, University Hospital, University of Parma, Parma, Italy.; Pisan I; Nephrology Unit, University Hospital, University of Parma, Parma, Italy.; Montecucco C; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia, Italy.; Santoro D; Nephrology and Dialysis Unit, University of Messina and G Martino Hospital, Messina, Italy.; Scolari F; Division of Nephrology and Dialysis, ASST SpedaliCivili and Università of Brescia, Brescia, Italy.; Mescia F; Division of Nephrology and Dialysis, ASST SpedaliCivili and Università of Brescia, Brescia, Italy.; Volpi S; Division of Paediatric Rheumatology and Scientific Institute for Research and Health Care, IRCCS Istituto Giannina Gaslini, Genoa, Italy.; Mosca M; Rheumatologu Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.; Tincani A; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.; Ravelli A; Division of Paediatric Rheumatology and Scientific Institute for Research and Health Care, IRCCS Istituto Giannina Gaslini, Genoa, Italy.; Murtas C; Nephrology and Dialysis Unit, Ospedale Belcolle, 01100 Viterbo, Italy.; Candiano G; Laboratory of Molecular Nephrology, IRCCS Istituto Giannina Gaslini, Genoa, Italy.; Caridi G; Laboratory of Molecular Nephrology, IRCCS Istituto Giannina Gaslini, Genoa, Italy.; La Porta E; Division of Nephrology, Dialysis and Transplantation, IRCCS Istituto Giannina Gaslini, Genoa, Italy.; Verrina E; Division of Nephrology, Dialysis and Transplantation, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Source
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101128967 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-0183 (Electronic) Linking ISSN: 15689972 NLM ISO Abbreviation: Autoimmun Rev Subsets: MEDLINE
Subject
Language
English
Abstract
Deposition of autoantibodies in glomeruli is a key factor in the development of lupus nephritis (LN). For a long time, anti-dsDNA and anti-C1q antibodies were thought to be the main cause of the kidney damage. However, recent studies have shown that the list of autoantibidies that have renal tropism and deposit in the kidney in LN is increasing and the link between anti-dsDNA and renal pathology is weak due to potential confounders. Aspecific bindings of dsDNA with cationic antibodies and of anti-dsDNA with several renal antigens such as actinin, laminin, entactin, and annexinA2 raised doubts about the specific target of these antibodies in the kidney. Moreover, the isotype of anti-dsDNA in SLE and LN has never received adequate interest until the recent observation that IgG2 are preponderant over IgG1, IgG3 and IgG4. Based on the above background, recent studies investigated the involvement of anti-dsDNA IgG2 and of other antibodies in LN. It was concluded that circulating anti-dsDNA IgG2 levels do not distinguish between LN versus non-renal SLE, and, in patients with LN, their levels do not change over time. Circulating levels of other antibodies such as anti-ENO1 and anti-H2 IgG2 were, instead, higher in LN vs non-renal SLE at the time of diagnosis and decreased following therapies. Finally, new classes of renal antibodies that potentially modify the anti-inflammatory response in the kidney are emerging as new co-actors in the pathogenetic scenario. They have been defined as 'second wave antibodies' for the link with detoxifying mechanisms limiting the oxidative stress in glomeruli that are classically stimulated in a second phase of inflammation. These findings have important clinical implications that may modify the laboratory approach to LN. Serum levels of anti-ENO1 and anti-H2 IgG2 should be measured in the follow up of patients for designing the length of therapies and identify those patients who respond to treatments. Anti-SOD2 could help to monitor and potentiate the anti-inflammatory response in the kidney.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier B.V.)
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier B.V.)