학술논문
Sex/gender-related differences in inflammaging.
Document Type
Academic Journal
Author
Olivieri F; Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy; Clinic of Laboratory and Precision Medicine, IRCCS INRCA, Ancona, Italy.; Marchegiani F; Clinic of Laboratory and Precision Medicine, IRCCS INRCA, Ancona, Italy.; Matacchione G; Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.; Giuliani A; Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.; Ramini D; Clinic of Laboratory and Precision Medicine, IRCCS INRCA, Ancona, Italy.; Fazioli F; Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.; Sabbatinelli J; Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy; Laboratory Medicine Unit, Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy. Electronic address: j.sabbatinelli@staff.univpm.it.; Bonafè M; Department of Experimental, Diagnostic, and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.
Source
Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 0347227 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6216 (Electronic) Linking ISSN: 00476374 NLM ISO Abbreviation: Mech Ageing Dev Subsets: MEDLINE
Subject
Language
English
Abstract
Geroscience puts mechanisms of aging as a driver of the most common age-related diseases and dysfunctions. Under this perspective, addressing the basic mechanisms of aging will produce a better understanding than addressing each disease pathophysiology individually. Worldwide, despite greater functional impairment, life expectancy is higher in women than in men. Gender differences in the prevalence of multimorbidity lead mandatory to the understanding of the mechanisms underlying gender-related differences in multimorbidity patterns and disability-free life expectancy. Extensive literature suggested that inflammaging is at the crossroad of aging and age-related diseases. In this review, we highlight the main evidence on sex/gender differences in the mechanisms that foster inflammaging, i.e. the age-dependent triggering of innate immunity, modifications of adaptive immunity, and accrual of senescent cells, underpinning some biomarkers of inflammaging that show sex-related differences. In the framework of the "gender medicine perspective", we will also discuss how sex/gender differences in inflammaging can affect sex differences in COVID-19 severe outcomes.
Competing Interests: Declaration of Interests None.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Competing Interests: Declaration of Interests None.
(Copyright © 2023 Elsevier B.V. All rights reserved.)