학술논문

The Impact of CoronaVac Vaccination on 28-day Mortality Rate of Critically Ill Patients with COVID-19 in Türkiye.
Document Type
Academic Journal
Author
Gül F; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Marmara University Faculty of Medicine, İstanbul, Türkiye.; Kasapoğlu US; Clinic of Critical Care Medicine, Malatya Training and Research Hospital, Malatya, Türkiye.; Sabaz MS; Clinic of Critical Care Medicine, Marmara University Pendik Training and Research Hospital, İstanbul, Türkiye.; Ay P; Department of Public Health, Marmara University Faculty of Medicine, İstanbul, Türkiye.; Oktay BD; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Marmara University Faculty of Medicine, İstanbul, Türkiye.; Çalışkan G; Department of Anesthesiology and Reanimation, University of Health Sciences Türkiye, Bursa Faculty of Medicine, Bursa, Türkiye.; Demir N; Division of Critical Care Medicine, Clinic of Chest Diseases, University of Health Sciences Türkiye, Ankara City Hospital, Ankara, Türkiye.; Sayan İ; Clinic of Critical Care Medicine, Sancaktepe Training and Research Hospital, İstanbul, Türkiye.; Kabadayı F; Clinic of Critical Care Medicine, Sancaktepe Training and Research Hospital, İstanbul, Türkiye.; Altuntaş G; Clinic of Critical Care Medicine, Elazığ City Hospital, Elazığ, Türkiye.; Gümüş A; Clinic of Critical Care Medicine, Antalya Kepez State Hospital, Antalya, Türkiye.; Kırca H; Clinic of Critical Care Medicine, Antalya Kepez State Hospital, Antalya, Türkiye.; Şanlı D; Clinic of Critical Care Medicine, Batman Training and Research Hospital, Batman, Türkiye.; Acil F; Clinic of Anesthesiology and Reanimation, University of Health Sciences Türkiye, Diyarbakır Gazi Yaşargil Training and Research Hospital, Diyabakır, Türkiye.; Dedeoğlu A; Clinic of Anesthesiology and Reanimation, University of Health Sciences Türkiye, Diyarbakır Gazi Yaşargil Training and Research Hospital, Diyabakır, Türkiye.; Ural SG; Clinic Critical Care Medicine, University of Health Sciences Türkiye, Erzurum City Hospital, Erzurum, Türkiye.; Akın Şen İ; Clinic Critical Care Medicine, University of Health Sciences Türkiye, Erzurum City Hospital, Erzurum, Türkiye.; Macit Aydın E; Division of Critical Care Medicine, Clinic of Anesthesiology and Reanimation, University of Health Sciences Türkiye, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Türkiye.; Dayanır H; Division of Critical Care Medicine, Clinic of Anesthesiology and Reanimation, University of Health Sciences Türkiye, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Türkiye.; Yelken B; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Türkiye.; Ceylan İ; Clinic of Critical Care Medicine, University of Health Sciences Türkiye, Bursa High Specialization Training and Research Hospital, Bursa, Türkiye.; Aydın OÖ; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Türkiye.; Eskidemir G; Clinic of Critical Care Medicine, Gaziosmanpaşa Training and Research Hospital, İstanbul, Türkiye.; Aytekin A; Clinic of Anesthesiology and Reanimation, Göztepe Prof. Dr. Süleyman Yalçın City Hospital, İstanbul, Türkiye.; Cengiz M; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Akdeniz University Faculty of Medicine, Antalya, Türkiye.; Arslan Ü; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Akdeniz University Faculty of Medicine, Antalya, Türkiye.; Akdağ D; Clinic of Critical Care Medicine, University of Health Sciences Türkiye, Adana City Hospital, Adana, Türkiye.; Alay GH; Department of Anesthesiology and Reanimation, University of Health Sciences Türkiye, İstanbul Başakşehir Çam and Sakura City Hospital, İstanbul, Türkiye.; Tekin E; Clinic of Critical Care Medicine, Denizli State Hospital, Denizli, Türkiye.; Yarar V; Clinic of Critical Care Medicine, Balıkesir Atatürk City Hospital, Balıkesir, Türkiye.; Saracoğlu KT; Clinic of Anesthesiology and Reanimation, University of Health Sciences Türkiye, Kartal Lütfi Kırdar Training and Research Hospital, İstanbul, Türkiye.; Gök F; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Necmettin Erbakan University Faculty of Medicine, Konya, Türkiye.; Alparslan V; Clinic of Critical Care Medicine, Hatay Training and Research Hospital, Hatay, Türkiye.; Tuna V; Clinic of Critical Care Medicine, Adıyaman Training and Research Hospital, Adıyaman, Türkiye.; Yıldız M; Clinic of Critical Care Medicine, Ağrı Training and Research Hospital, Ağrı, Türkiye.; Şenoğlu N; Division of Critical Care Medicine, Clinic of Anesthesiology and Reanimation, University of Health Sciences Türkiye, Tepecik Training and Research Hospital, İzmir, Türkiye.; Kıraklı C; Department of Critical Care Medicine, University of Health Sciences Türkiye, Dr. Suat Seren Chest Diseases and Thoracic Surgery Training and Research Hospital, İzmir, Türkiye.; Yıldırım S; Department of Critical Care Medicine, University of Health Sciences Türkiye, Dr. Suat Seren Chest Diseases and Thoracic Surgery Training and Research Hospital, İzmir, Türkiye.; Saçar Kübüç K; Clinic of Critical Care Medicine, University of Health Sciences Türkiye, Van Training and Research Hospital, Van, Türkiye.; Erer A; Clinic of Critical Care Medicine, Tekirdağ İsmail Fehmi Cumalioğlu City Hospital, Tekirdag, Türkiye.; Gültekin H; Clinic of Critical Care Medicine, Şırnak State Hospital, Şırnak, Türkiye.; Özmen Süner K; Clinic of Critical Care Medicine, Sakarya Training and Research Hospital, Sakarya, Türkiye.; Kuzgun Ö; Clinic of Critical Care Medicine, Sakarya Training and Research Hospital, Sakarya, Türkiye.; Öztürk ÇE; Clinic of Critical Care Medicine, University of Health Sciences Türkiye, Samsun Training and Research Hospital, Samsun, Türkiye.; Karahan A; Clinic of Critical Care Medicine, Mersin City Hospital, Mersin, Türkiye.; Deveci O; Clinic of Critical Care Medicine, Mersin City Hospital, Mersin, Türkiye.; Ay M; Clinic of Anesthesiology and Reanimation, Antalya Training and Research Hospital, Antalya, Türkiye.; Tüfek Öztan D; Clinic of Anesthesiology and Reanimation, Antalya Training and Research Hospital, Antalya, Türkiye.; Akıncı SB; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Hacettepe University Faculty of Medicine, Ankara, Türkiye.; Yalçın Solak M; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Hacettepe University Faculty of Medicine, Ankara, Türkiye.; Bozbay S; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Hitit University Faculty of Medicine, Çorum, Türkiye.; Özçiftçi S; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Hitit University Faculty of Medicine, Çorum, Türkiye.; Gönderen K; Department of Critical Care Medicine, İzmir Katip Çelebi University, Atatürk Training and Research Hospital, İzmir, Türkiye.; Küçük AO; Division of Critical Care Medicine, Department of Chest Diseases, Karadeniz Technical University Faculty of Medicine, Trabzon, Türkiye.; Uyan B; Department Critical Care Medicine, Gaziantep Şehit Kamil State Hospital, Gaziantep, Türkiye.; Elay G; Division of Critical Care Medicine, Department of Internal Medicine, Gaziantep University Faculty of Medicine, Gaziantep, Türkiye.; Boyacı N; Division of Critical Care Medicine, Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Türkiye.; Timurkaan M; Clinic of Critical Care Medicine, Elazığ City Hospital, Elazığ, Türkiye.; Karakoç E; Department of Critical Care Medicine, Çankırı State Hospital, Çankırı, Türkiye.; Doğan L; Department of Critical Care Medicine, Altunizade Acıbadem Hospital, İstanbul, Türkiye.; Yalçınkaya E; Department of Critical Care Medicine, Sivas Numune Hospital, Sivas, Türkiye.; Kazancıoğlu L; Department of Anesthesiology and Reanimation, Recep Tayyip Erdoğan University Faculty of Medicine, Rize, Türkiye.; Erdal Dönmez G; Department of Critical Care Medicine, University of Health Sciences Türkiye, İstanbul Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, Türkiye.; Yılmaz B; Department of Critical Care Medicine, University of Health Sciences Türkiye, İstanbul Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, Türkiye.; Ergül DF; Department of Critical Care Medicine, Amasya University Sabuncuoğlu Şerafettin Training and Research Hospital, Amasya, Türkiye.; Boran M; Department of Critical Care Medicine, Amasya University Sabuncuoğlu Şerafettin Training and Research Hospital, Amasya, Türkiye.; Özkarakaş H; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, University of Health Sciences Türkiye, İzmir Bozyaka Training and Research Hospital, İzmir, Türkiye.; Karakaş B; Clinic of Critical Care Medicine, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Türkiye.; Ergin Özcan P; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, İstanbul University Capa Faculty of Medicine, İstanbul, Türkiye.; Anaklı İ; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, İstanbul University Capa Faculty of Medicine, İstanbul, Türkiye.; Bayar MK; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Ankara University Faculty of Medicine, Ankara, Türkiye.; Yüksel DY; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Ankara University Faculty of Medicine, Ankara, Türkiye.; Akdağ Ş; Department of Anesthesiology and Reanimation, Yasar Eryılmaz Ağrı Doğubeyazıt State Hospital, Ağrı, Türkiye.; Pişkin Ö; Department of Anesthesiology and Reanimation, Zonguldak Bülent Ecevit University Faculty of Medicine, Zonguldak, Türkiye.; Temur S; Department of Anesthesiology and Reanimation, Yeditepe University Faculty of Medicine, İstanbul, Türkiye.; Eyüpoğlu S; Clinic of Critical Care Medicine, Giresun Training and Research Hospital, Giresun, Türkiye.; Tekir Yılmaz E; Clinic of Anesthesiology and Reanimation, Giresun University Faculty of Medicine, Giresun Training and Research Hospital, Giresun, Türkiye.; Avcı GZ; Clinic of Anesthesiology and Reanimation, Giresun Prof. Dr. İlhan Özdemir State Hospital, Giresun Türkiye.; Turan R; Clinic of Anesthesiology and Reanimation, Giresun Prof. Dr. İlhan Özdemir State Hospital, Giresun Türkiye.; Alkan Bayburt F; Clinic of Anesthesiology and Reanimation, Giresun Prof. Dr. İlhan Özdemir State Hospital, Giresun Türkiye.; Şahintürk H; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Başkent University Faculty of Medicine, Ankara, Türkiye.; Güçyetmez B; Department of Anesthesiology and Reanimation, Acıbadem Mehmet Ali Aydınlar University Faculty of Medicine, İstanbul, Türkiye.; Alparslan MM; Clinic of Anesthesiology and Reanimation, Aksaray University Training and Research Hospital, Aksaray, Türkiye.; Yarıcı M; Department of Critical Care Medicine, University of Health Sciences Türkiye, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Türkiye.; Yıldırım F; Department of Chest Diseases, University of Health Sciences Türkiye, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Türkiye.; Yektaş A; Department of Anesthesiology and Reanimation, Siirt University Faculty of Medicine, Siirt, Türkiye.; Yaman G; https://gucluyaman.com/tr/.; Demirkıran O; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, İstanbul, Türkiye.; Cinel İ; Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Marmara University Faculty of Medicine, İstanbul, Türkiye.
Source
Publisher: Galenos Publishing House Country of Publication: Turkey NLM ID: 101571817 Publication Model: Print Cited Medium: Internet ISSN: 2146-3131 (Electronic) Linking ISSN: 21463123 NLM ISO Abbreviation: Balkan Med J Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Vaccines against coronavirus disease-19 (COVID-19) have been effective in preventing symptomatic diseases, hospitalizations, and intensive care unit (ICU) admissions. However, data regarding the effectiveness of COVID-19 vaccines in reducing mortality among critically ill patients with COVID-19 remains unclear.
Aims: To determine the vaccination status and investigate the impact of the COVID-19 vaccine on the 28-day mortality in critically ill patients with COVID-19.
Study Design: Multicenter prospective observational clinical study.
Methods: This study was conducted in 60 hospitals with ICUs managing critically ill patients with COVID-19. Patients aged ≥ 18 years with confirmed COVID-19 who were admitted to the ICU were included. The present study had two phases. The first phase was designed as a one-day point prevalence study, and demographic and clinical findings were evaluated. In the second phase, the 28-day mortality was evaluated.
Results: As of August 11, 2021, 921 patients were enrolled in the study. The mean age of the patients was 65.42 ± 16.74 years, and 48.6% (n = 448) were female. Among the critically ill patients with COVID-19, 52.6% (n = 484) were unvaccinated, 7.7% (n = 71) were incompletely vaccinated, and 39.8% (n = 366) were fully vaccinated. A subgroup analysis of 817 patients who were unvaccinated (n = 484) or who had received two doses of the CoronaVac vaccine (n = 333) was performed. The 28-day mortality rate was 56.8% (n = 275) and 57.4% (n = 191) in the unvaccinated and two-dose CoronaVac groups, respectively. The 28-day mortality was associated with age, hypertension, the number of comorbidities, type of respiratory support, and APACHE II and sequential organ failure assessment scores ( p < 0.05). The odds ratio for the 28-day mortality among those who had received two doses of CoronaVac was 0.591 (95% confidence interval: 0.413-0.848) ( p = 0.004).
Conclusion: Vaccination with at least two doses of CoronaVac within six months significantly decreased mortality in vaccinated patients than in unvaccinated patients.